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Neuropathology, 3rd Edition. A Volume in the Series: Foundations in Diagnostic Pathology

ISBN: 9780323713443
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Διαστάσεις 28 × 22 cm
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Περιγραφή

Now fully revised to include recent advances in the field, the third edition of Neuropathology, a volume in the Foundations in Diagnostic Pathology series, is an essential foundation text for residents and pathologists. The popular template format makes it easy to use, and new information throughout brings you up to date with what’s new in the field, including advances in molecular diagnostic testing and new diagnostic biomarkers. Practical and affordable, this resource is ideal for study and review as well as everyday clinical practice.
Key Features

Key features of this practical text include:

  • A consistent, user-friendly format that explores each entity’s clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnoses, and prognostic and therapeutic considerations.
  • A focus on specific features of selected neoplastic and non-neoplastic entities, including broad and in-depth differential diagnoses.
  • Review of normal histology before examining abnormal findings, enabling you to conveniently compare their characteristics in one place at one time.
  • Clinical information on treatment and prognosis, enabling you to better understand the clinical implications of the diagnosis.
  • Nearly 600 full-color, high-quality illustrations with extensive figure legends, as well as abundant boxes and tables throughout.
  • Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

 

What’s NEW in this edition:

  • Advances in molecular diagnostic testing and its capabilities and limitations, including targeted/personalized medicine.
  • New diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities.
  • The latest TNM staging and WHO classification systems.
Author Information
Edited by Richard A. Prayson, MD MEd, Head, Section of Neuropathology Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH and Gabrielle A. Yeaney, MD , Associate Professor of Pathology, Cleveland Clinic Lerner College of Medicine

Περιεχόμενα

Cover Image
Other books in this series
Title Page
Copyright
Contributors
Foreword
Preface
Acknowledgements
Table of Contents
Chapter 1 Overview of Central Nervous System Anatomy and Histology
GROSS ANATOMY
CELL TYPES
TISSUE ORGANIZATION
FEATURES OF INFANCY AND CHILDHOOD
NORMAL AGING AND COMMON ARTIFACTS
SUGGESTED READINGS
Chapter 2 Vascular Disease
CAUSES OF REDUCED BLOOD FLOW OR OXYGENATION
CAUSES OF CEREBRAL HEMORRHAGE
Cavernous Angioma
SUGGESTED READINGS
Chapter 3 Trauma
SCALP INJURY
SKULL FRACTURE
EPIDURAL HEMORRHAGE
SUBDURAL HEMORRHAGE
SUBARACHNOID HEMORRHAGE
CEREBRAL CONTUSION
DIFFUSE TRAUMATIC BRAIN INJURY
GUNSHOT WOUNDS
PEDIATRIC HEAD INJURY
SEQUELAE OF TRAUMATIC BRAIN INJURY
SPINAL CORD INJURY
SUGGESTED READINGS
Chapter 4 Congenital Malformations, Perinatal Diseases, and Tumor Predisposition Syndromes
BRAIN DEVELOPMENT AND MALFORMATIONS: GENERAL PRINCIPLES
MALFORMATIONS OF THE CENTRAL NERVOUS SYSTEM
Chapter 5 Demyelinating Disorders
OVERVIEW OF CHAPTER
MULTIPLE SCLEROSIS
PML AND PRIMARY CNS LYMPHOMA AS DIAGNOSTIC CONSIDERATIONS FOR ACUTE/TUMEFACTIVE DEMYELINATING LESIONS PROMPTING BIOPSY
MYELIN OLIGODENDROCYTE GLYCOPROTEIN ANTIBODY DISEASE
MACROSCOPIC FEATURES OF MULTIPLE SCLEROSIS AT AUTOPSY
MICROSCOPIC FEATURES OF MULTIPLE SCLEROSIS AT AUTOPSY
OVERVIEW OF LEUKODYSTROPHIES
ADRENOLEUKODYSTROPHY
METACHROMATIC LEUKODYSTROPHY
GLOBOID CELL LEUKODYSTROPHY (KRABBE DISEASE)
ALEXANDER DISEASE
CANAVAN DISEASE
PELIZAEUS-MERZBACHER DISEASE
SUGGESTED READINGS
Chapter 6 Neurodegenerative Diseases
DEMENTIA AND AGE-RELATED PATHOLOGIES
PARKINSONIAN AND ATYPICAL PARKINSONIAN SYNDROMES
MOTOR NEURON DISEASES
ACKNOWLEDGMENTS
SUGGESTED READINGS
Chapter 7 Infections
BACTERIAL INFECTIONS
FUNGAL INFECTIONS
VIRAL INFECTIONS
PARASITIC INFECTIONS
SPONGIFORM ENCEPHALOPATHIES
SUGGESTED READINGS
Chapter 8 Metabolic and Toxic Disorders
LYSOSOMAL STORAGE DISEASES
PEROXISOMAL DISORDERS
MITOCHONDRIAL DISORDERS
DISORDERS OF AMINO ACID METABOLISM AND MISCELLANEOUS INHERITED METABOLIC DISORDERS
CONGENITAL DISORDERS OF GLYCOSYLATION (CARBOHYDRATE-DEFICIENT GLYCOPROTEIN SYNDROMES)
ACQUIRED METABOLIC DISORDERS
NUTRITIONAL CENTRAL NERVOUS SYSTEM DISORDERS
NEUROTOXICOLOGY
SUGGESTED READINGS
Chapter 9 Glial and Glioneuronal Tumors
DIFFUSE ASTROCYTOMAS
PILOCYTIC ASTROCYTOMA
SUBEPENDYMAL GIANT CELL ASTROCYTOMA
PLEOMORPHIC XANTHOASTROCYTOMA
ASTROBLASTOMA
DESMOPLASTIC INFANTILE ASTROCYTOMA/GANGLIOGLIOMA
CHORDOID GLIOMA
ANGIOCENTRIC GLIOMA
OLIGODENDROGLIOMA
EPENDYMOMA
MYXOPAPILLARY EPENDYMOMA
SUBEPENDYMOMA
GANGLIOGLIOMA AND GANGLION CELL TUMORS
DYSEMBROPLASTIC NEUROEPITHELIAL TUMOR
PAPILLLARY GLIONEURONAL TUMOR
ROSETTE-FORMING GLIONEURONAL TUMOR
OTHER NEURONAL-GLIAL TUMORS
NASAL GLIAL HETEROTOPIA
SUGGESTED READINGS
Chapter 10 Non-glial Tumors
MENINGIOMAS
MESENCHYMAL TUMORS
HEMANGIOBLASTOMA
PRIMARY MELANOCYTIC LESIONS
CHORDOMA
CHOROID PLEXUS TUMORS
NEUROCYTOMA
EMBRYONAL TUMORS
SCHWANNOMAS
LYMPHOMA
HISTIOCYTIC TUMORS
CYSTS
GERM CELL TUMORS
PITUITARY TUMORS
PINEAL TUMORS
CRANIOPHARYNGIOMA
PARAGANGLIOMA
METASTASIS
SUGGESTED READINGS
Chapter 11 Skeletal Muscle and Peripheral Nerve Disorders
DISORDERS OF INNERVATION (DENERVATION ATROPHY)
DISORDERS OF NEUROMUSCULAR TRANSMISSION (AUTOIMMUNE MYASTHENIA, MYASTHENIA GRAVIS)
DISORDERS OF EXCITATION–CONTRACTION COUPLING (MUSCLE CHANNELOPATHIES)
CORE MYOPATHIES
DISORDERS OF THE SARCOMERE
LATE-ONSET MYOFIBRILLAR MYOPATHY/Z-DISC DISEASES
DISORDERS OF MECHANICAL TRANSDUCTION (MUSCULAR DYSTROPHIES)
LIMB-GIRDLE MUSCULAR DYSTROPHIES
CONGENITAL MUSCULAR DYSTROPHIES
DISORDERS OF ENERGY METABOLISM
MITOCHONDRIAL ENCEPHALOMYOPATHIES
DISORDERS OF IMMUNITY (INFLAMMATORY MYOPATHIES)
IMMUNE-MEDIATED NECROTIZING MYOPATHY
DISORDERS OF IATROCHEMISTRY (TOXIC MYOPATHIES)
INTRODUCTION TO PERIPHERAL NERVES
SUGGESTED READINGS
Index