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Practical Pulmonary Pathology, 4th Edition A Diagnostic Approach

ISBN: 9780323795470
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Περιγραφή

Part of the in-depth and practical Pattern Recognition series, Practical Pulmonary Pathology, 4th Edition, helps you arrive at an accurate diagnosis by using a pattern-based approach. Leading diagnosticians in pulmonary pathology offer practical assistance in identifying all major neoplastic and non-neoplastic diseases of the lungs, guiding you from a pathological pattern through the appropriate work-up, around the pitfalls, and to the best diagnosis. More than 1,000 high-quality illustrations capture key morphologic patterns for a full range of common and rare conditions and assist in the interpretation of complex diagnostic puzzles. A unique “visual index” at the beginning of the book directs you to the exact chapter and specific page you need for in-depth diagnostic guidance.
Key Features
  • Helps you quickly recognize the vast variety of appearances of the lung that result from infections, tumors, and tumor-like lesions, both malignant and benign.
  • Discusses advances in molecular diagnostic testing, its capabilities and its limitations, including targeted/personalized medicine.
  • Incorporates clinicopathologic background and relevant data from ancillary techniques (immunohistochemistry, cytogenetics, and molecular genetics), giving you the tools you need to master the latest breakthroughs in diagnostic technology.
  • Covers the latest TNM staging and WHO classification systems, as well as new diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities.
  • Color-codes patterns to specific entities, and summarizes key points in tables, charts, and graphs so you can quickly and easily find what you are looking for.
  • Shares the knowledge and expertise of new co-editor, Dr. Maxwell L. Smith.
  • Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Author Information
Edited by Maxwell L. Smith, MD, Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, Arizona; Kevin O. Leslie, MD, Professor of Pathology, Mayo Clinic Arizona, Scottsdale, Arizona, USA and Mark R. Wick, MD, Professor of Pathology, University of Virginia Health System, Charlottesville, Virginia, USA

Περιεχόμενα

Cover image
Title page
Table of Contents
Copyright
List of Contributors
Series Preface
Preface
Pattern Based Approach to Diagnosis
List of Tables
List of Illustrations
1. Lung anatomy
Development and gross anatomy
Microscopic anatomy
Pulmonary arteries
Pulmonary veins
Bronchial arteries
Pulmonary lymphatics
Other pulmonary lymphoid tissue
Composite microscopic anatomy and relationship to distribution of lung diseases
References
2. Pulmonary function testing for pathologists
Lung volumes
Tools to measure volumes
Interpretation of lung volumes
Flows
Airway resistance
Summary
References
3. Optimal processing of diagnostic lung specimens
Specimens obtained through the flexible bronchoscope
Specimens obtained by transthoracic needle biopsy and aspiration
Specimens obtained by thoracoscopy
Conclusion
References
4. Computed tomography of diffuse lung diseases and solitary pulmonary nodules
Foundations
Diffuse lung diseases
Septal pattern
Fibrotic pattern
Nodular pattern
Alveolar pattern
Cystic pattern
Dark lung pattern
Imaging of the solitary pulmonary nodule
References
5. Developmental and pediatric lung disease
Processing of pediatric lung biopsy specimens
Processing of pediatric cystic lung lesion specimens
Cysts and masses
Pulmonary hyperlucency
Disorders of lung development
Vascular disorders
Complications of prematurity
Pediatric interstitial lung disease
References
6. Acute lung injury
Practical approach to the differential diagnosis of acute lung injury for pathologists
History and nomenclature of acute lung injury, acute respiratory distress syndrome, diffuse alveolar damage, and acute interstitial pneumonia
Diffuse alveolar damage: The morphologic prototype of acute lung injury
Specific causes of acute lung injury
Clinicopathologic correlation
References
7. Lung infections
Histologic patterns of lung infection
Useful tools and strategies
Agents of infection
Mycobacterial infections
Fungal pneumonias
Viral pneumonia
Parasitic infections
References
8. Chronic diffuse lung diseases
Patterns encountered in this chapter
Idiopathic interstitial pneumonias
Chronic manifestations of systemic collagen vascular disease
Diffuse eosinophilic lung disease (pulmonary eosinophilia)
Drug-associated diffuse lung disease
Diffuse lung diseases with granulomas
Miscellaneous diffuse lung diseases
Practical approach to the differential diagnosis of diffuse lung diseases
References
9. Nonneoplastic pathology of the large and small airways
Large airways: Trachea and bronchi
Small airways
Clinicopathologic entities with prominent airway manifestations
Occupational airway diseases
References
10. Pneumoconioses
Overview and general considerations
Types of pneumoconiosis
References
11. Pulmonary vasculitis and pulmonary hemorrhage
Pulmonary vasculitis
Pulmonary hemorrhage
References
12. Pulmonary hypertension
Introduction
Morphologic features of the pulmonary vasculature
Definition of pulmonary hypertension
Classification and genetics of pulmonary hypertension
Pathologic features of pulmonary hypertension
Thrombotic and embolic hypertension
Pulmonary venous hypertension
Pulmonary hypertension secondary to intrinsic lung disease or hypoxia
Morphologic mimics of pulmonary hypertension
Pathogenesis and treatment of pulmonary hypertension
References
13. Pathology of lung transplantation
Introduction
Pulmonary allograft rejection
Chronic lung allograft dysfunction
Infection
Posttransplantation lymphoproliferative disorders
Transplantation procedure-related complications
Recurrence of the primary disease
Aspiration
Donor-related pathology
References
14. Neuroendocrine neoplasms of the lung
Introduction and general considerations
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia
Carcinoid tumor
Atypical carcinoid
Large cell neuroendocrine carcinoma
Small cell carcinoma
Primitive neuroectodermal tumor
Other rare neuroendocrine tumors
References
15. Sarcomas and sarcomatoid neoplasms of the lungs and pleural surfaces
Introduction
General concepts
Pleomorphic spindle cell neoplasms
Monomorphic spindle cell neoplasms
Epithelioid and rhabdoid malignancies
Small round cell sarcomas
References
16. Hematolymphoid disorders
Special studies
Reactive lymphoid proliferations
Neoplastic and malignant lymphoid proliferations
Myeloid proliferations
References
17. Non-neuroendocrine carcinomas (excluding sarcomatoid carcinoma) and salivary gland-type tumors of the lung
Lung carcinoma: General considerations
Specific subtypes of lung carcinoma (excluding neuroendocrine and sarcomatoid carcinomas)
Practical approach to the diagnosis of lung carcinoma in small biopsy specimens, including cytology specimens
Approach to the diagnosis of lung carcinoma in resection specimens
References
18. Metastatic tumors in the lung: A practical approach to diagnosis
Pathophysiologic methods of malignant spread
Pleural metastases
Endobronchial metastases
Modalities for the diagnosis of pleuropulmonary metastases
Practical approach to differential diagnosis
References
19. Pseudoneoplastic lesions of the lungs and pleural surfaces
Mesenchymal lesions
Fibroinflammatory lesions
Lymphoid lesions
Epithelioid lesions
Reactive/atypical II pneumocytes
Other
Pseudoneoplastic lesions of the pleural surfaces
References
20. Benign and borderline tumors of the lungs and pleura
Benign pleuropulmonary neoplasms
Benign tumors that are principally tracheal and endobronchial
Benign lesions affecting either the airways or the lung parenchyma
Benign tumors of the pleura
Biologically borderline tumors of the lung and pleura
Other lesions
References
21. Malignant and borderline mesothelial tumors of the pleura
Mesothelioma
Etiologic considerations in pleural mesothelioma
Molecular genetics of mesothelioma
Gross features of pleural mesothelioma
Histopathologic features of pleural mesothelioma
Cytopathologic features of pleural mesothelioma
Histochemical features of pleural mesothelioma
Electron microscopic features of pleural mesothelioma
Immunohistochemical findings in pleural mesothelioma
Differential diagnosis of benign versus malignant mesothelial proliferations
Differential diagnosis of epithelioid pleural mesothelioma
Benign and borderline (low-grade malignant) mesothelial tumors
Staging and grading of malignant mesothelioma
References
Appendix: Miscellaneous distinctive histopathologic findings
Index