Περιεχόμενα
SECTION 1: INTRODUCTION AND OVERVIEW
4 Introduction to Renal Pathology
Robert B. Colvin, MD
24 Normal Kidney Structure
Neeraja Kambham, MD and Anthony Chang, MD
36 Normal Kidney Development
Sanjay Jain, MD, PhD and Yasar Caliskan, MD
46 Kidney Biopsy Evaluation and Reports
Lynn D. Cornell, MD, Surya V. Seshan, MD, and Anthony
Chang, MD
50 Harmonized Nephropathy Terminology
Mark Haas, MD
54 Common Artifacts and Pitfalls
Lynn D. Cornell, MD
SECTION 2: GLOMERULAR DISEASES
PODOCYTOPATHIES
60 Minimal Change Disease
A. Brad Farris, III, MD and Astrid Weins, MD, PhD
68 Classification of Focal Segmental Glomerulosclerosis
A. Brad Farris, III, MD and Astrid Weins, MD, PhD
72 Etiologic Classification of Focal Segmental
Glomerulosclerosis
Robert B. Colvin, MD
74 Focal Segmental Glomerulosclerosis, Primary
A. Brad Farris, III, MD and Astrid Weins, MD, PhD
82 Focal Segmental Glomerulosclerosis, Adaptive
(Secondary)
A. Brad Farris, III, MD and Astrid Weins, MD, PhD
88 Collapsing Glomerulopathy
A. Brad Farris, III, MD and Astrid Weins, MD, PhD
MEMBRANOUS NEPHROPATHY AND VARIANTS
98 Introduction to Membranous Nephropathy
Robert B. Colvin, MD
108 Etiologies of Membranous
Glomerulonephritis_Table
Robert B. Colvin, MD
110 Introduction to Membranous Nephropathy
Anthony Chang, MD
116 Mebranous Nephropathy Due to PLA2R
Autoantibodies
Anthony Chang, MD and Sanjeev Sethi, MD
120 Membranous Nephropathy Due to non-PLA2R
Antibodies
Anthony Chang, MD and Sanjeev Sethi, MD
124 Membranous Nephropathy Associated With
Systemic Disease
Anthony Chang, MD
128 Membranous Nephropathy With Organized Deposits
Anthony Chang, MD
132 Membranous Nephropathy With Anti-TBM
Antibodies
Robert B. Colvin, MD
134 Podocyte Infolding Glomerulopathy
Shane Meehan, MB, BCh
IGA-RELATED GLOMERULONEPHRITIS
136 Overview of IgA-Related Glomerular Diseases
Shane Meehan, MB, BCh
140 IgA Nephropathy
Lynn D. Cornell, MD, Robert B. Colvin, MD, and Ian Roberts, MBChB, FRCPath
154 IgA Vasculitis (Henoch-Schönlein Purpura)
Anthony Chang, MD and Ian Roberts, MBChB, FRCPath
160 IgA Acute Glomerulonephritis Associated With
Staphylococcus aureus
Robert B. Colvin, MD and Ian Roberts, MBChB, FRCPath
164 Hepatic Disease With IgA Deposition
Robert B. Colvin, MD
SLE AND RELATED AUTOANTIBODYMEDIATED DISEASES
166 Systemic Lupus Erythematosus
Shane Meehan, MB, BCh, Robert B. Colvin, MD, and Ingeborg Bajema, MD
184 Mixed Connective Tissue Disease
A. Brad Farris, III, MD
186 Idiopathic Nonlupus Full-House Nephropathy
Ingeborg Bajema, MD and Emilie Rijnink, MD, PhD
188 Mixed Cryoglobulinemic Glomerulonephritis
A. Brad Farris, III, MD and Charles Alpers, MD
ANTI-GBM DISEASES
194 Anti-GBM Glomerulonephritis
Anthony Chang, MD
202 Atypical Anti-GBM Disease
Lynn D. Cornell, MD
COMPLEMENT-RELATED GLOMERULONEPHRITIS
206 Classification of MPGN and Complement-Related Diseases
Robert B. Colvin, Md
210 Dense Deposit Disease
A. Brad Farris, III, MD
216 C3 Glomerulonephritis
Lynn D. Cornell, MD
222 C1q Nephropathy
Neeraja Kambham, MD
228 C4 Glomerulopathy
Sanjeev Sethi, MD
232 MPGN With Immune Complexes
A. Brad Farris, III, MD, Jean Hou, MD, and Mark Haas, MD
MONOCLONAL IMMUNOGLOBULIN DISEASES OF GLOMERULI
240 Introduction to Diseases With Monoclonal
Immunoglobulin Deposits
Robert B. Colvin, MD
244 Monoclonal Immunoglobulin Deposition Disease
Lynn D. Cornell, MD
252 Proliferative Glomerulonephritis With Monoclonal
IgG Deposits
Lynn D. Cornell, MD
256 Membranous Glomerulonephritis With Masked IgG κ
Deposits
Christopher P. Larsen, MD and Tiffany Caza, MD
260 Type I Cryoglobulinemic Glomerulonephritis
Robert B. Colvin, MD and Evan Farkash, MD, PhD
264 Waldenström Macroglobulinemia
Anthony Chang, MD
266 Crystalglobulin Glomerulonephritis
Anthony Chang, MD and Mariam Priya Alexander, MD
AMYLOIDOSIS
270 Amyloidosis Classification
A. Brad Farris, III, MD and Sanjeev Sethi, MD
276 AL/AH Amyloidosis
A. Brad Farris, III, MD and Sanjeev Sethi, MD
282 AA Amyloidosis
A. Brad Farris, III, MD and Sanjeev Sethi, MD
286 AFib Amyloidosis
A. Brad Farris, III, MD and Sanjeev Sethi, MD
288 AGel Amyloidosis
Sanjeev Sethi, MD
290 ALECT2 Amyloidosis
Christopher P. Larsen, MD, Sanjeev Sethi, MD, and Tiffany Caza, MD
292 AApoAI Amyloidosis
A. Brad Farris, III, MD and Sanjeev Sethi, MD
293 AApoAII Amyloidosis
Robert B. Colvin, MD and Sanjeev Sethi, MD
294 AApoAIV Amyloidosis
Sanjeev Sethi, MD
295 AApoCII Amyloidosis
Sanjeev Sethi, MD
296 ATTR Amyloidosis
A. Brad Farris, III, MD and Sanjeev Sethi, MD
IDIOPATHIC FIBRILLARY GLOMERULOPATHIES
298 Diseases With Organized Deposits
Robert B. Colvin, MD
302 Fibrillary Glomerulopathy
Anthony Chang, MD
308 Immunotactoid Glomerulopathy
Anthony Chang, MD and Charles Alpers, MD
312 Fibronectin Glomerulopathy
Neeraja Kambham, MD
DIABETIC AND RELATED RENAL DISEASE
316 Diabetic Nephropathy
Neeraja Kambham, MD and Ian Roberts, MBChB, FRCPath
326 Metabolic Syndrome/Obesity-Related Glomerular Disease
Shane Meehan, MB, BCh
330 Idiopathic Nodular Glomerulopathy
A. Brad Farris, III, MD and Ian Roberts, MBChB, FRCPath
INFECTION-RELATED GLOMERULAR DISEASE
334 Overview of Infection-Related Glomerular Disease
Shane Meehan, MB, BCh
338 Acute Poststreptococcal Glomerulonephritis
A. Brad Farris, III, MD
346 Postinfectious Glomerulonephritis,
Nonstreptococcal
A. Brad Farris, III, MD
352 Glomerulonephritis of Chronic Infection, Including
Shunt Nephritis
A. Brad Farris, III, MD
354 Endocarditis
A. Brad Farris, III, MD and Christie L. Boils, MD
358 Syphilis
Shane Meehan, MB, BCh
360 Lyme Disease
Neeraja Kambham, MD
362 COVID-19 Nephropathies
Lynn D. Cornell, MD, Mariam Priya Alexander, MD, and Robert B. Colvin, MD
366 Hepatitis B Virus
Anthony Chang, MD
370 Hepatitis C Virus
Anthony Chang, MD and Charles Alpers, MD
376 Hepatitis B Virus
Anthony Chang, MD
380 HIV-Associated Nephropathy
A. Brad Farris, III, MD
386 Miscellaneous HIV-Associated Renal Diseases
A. Brad Farris, III, MD
392 Schistosomiasis
Neeraja Kambham, MD
394 Filariasis
Christie L. Boils, MD and Tiffany Caza, MD
395 Leishmaniasis
Kerstin Amann, MD and Robert B. Colvin, MD
DRUG-INDUCED GLOMERULAR DISEASES
396 Drug-Induced Minimal Change Disease
Anthony Chang, MD and Astrid Weins, MD, PhD
398 Bisphosphonate-Induced Collapsing Glomerulopathy
A. Brad Farris, III, MD and Astrid Weins, MD, PhD
399 Chloroquine Toxicity
Shane Meehan, MB, BCh
400 Antihepatitis C Virus Drugs
Ivy A. Rosales, MD
404 Anti-EGFR Drugs
Kammi J. Henriksen, MD
GENETIC DISEASES OF GLOMERULUS
406 Overview and Classification of Genetic Diseases of Glomerulus
Sanjay Jain, MD, PhD and Yasar Caliskan, MD
408 Genetic Causes of Nephrotic Syndrome
Joseph P. Gaut, MD, PhD
GENETIC DISEASES OF GLOMERULAR BASEMENT MEMBRANE COLLAGEN
412 Alport Syndrome
Joseph P. Gaut, MD, PhD, Helen Liapis, MD, and Robert B. Colvin, MD
424 Thin Basement Membrane Disease
Joseph P. Gaut, MD, PhD and Helen Liapis, MD
GENETIC DISEASES OF PODOCYTE
426 Diffuse Mesangial Sclerosis
Joseph P. Gaut, MD, PhD and Helen Liapis, MD
430 Congenital Nephrotic Syndrome of Finnish Type
Joseph P. Gaut, MD, PhD and Helen Liapis, MD
434 Pierson Syndrome
Joseph P. Gaut, MD, PhD and Helen Liapis, MD
436 Galloway-Mowat Syndrome
Stephen M. Bonsib, MD
438 Denys-Drash Syndrome
Kammi J. Henriksen, MD and Stephen M. Bonsib, MD
442 Frasier Syndrome
Stephen M. Bonsib, MD
446 Podocin Deficiency
Joseph P. Gaut, MD, PhD and Helen Liapis, MD
448 α-Actinin-4 Deficiency
Joseph P. Gaut, MD, PhD and Helen Liapis, MD
450 Autosomal Dominant FSGS Due To INF2 Mutations
Robert B. Colvin, MD
452 APOL1-Related Glomerular Disease
Christopher P. Larsen, MD and Tiffany Caza, MD
456 Schimke Immunoosseous Dysplasia
Shane Meehan, MB, BCh
GENETIC STORAGE AND LIPID DISEASES
458 Fabry Disease
Robert B. Colvin, MD and Laura Barisoni, MD
466 Alagille Syndrome
Anthony Chang, MD
468 Lecithin Cholesterol Acyltransferase Deficiency
Carrie L. Phillips, MD and Stephen M. Bonsib, MD
472 APOE Lipoprotein Glomerulopathy
Joseph P. Gaut, MD, PhD and Helen Liapis, MD
474 Type III Hyperlipoproteinemia
Joseph P. Gaut, MD, PhD and Helen Liapis, MD
476 I-Cell Disease (Mucolipidosis II)
Stephen M. Bonsib, MD
478 Gaucher Glomerulopathy
A. Brad Farris, III, MD
OTHER GENETIC DISEASES AFFECTING GLOMERULUS
480 Type III Collagen Glomerulopathy
Joseph P. Gaut, MD, PhD, L. Nicholas Cossey, MD, FCAP, and Helen Liapis, MD
484 Nail-Patella Syndrome
Joseph P. Gaut, MD, PhD and Helen Liapis, MD
486 Glomerulopathy of Hereditary Multiple Exostoses
Robert B. Colvin, MD and Ian Roberts, MBChB, FRCPath
MISCELLANEOUS GLOMERULAR DISEASES
488 Cryofibrinogenic Glomerulopathy
Lynn D. Cornell, MD and Mariam Priya Alexander, MD
492 IgM Nephropathy
Neeraja Kambham, MD
494 IgG Nephropathy
Anthony Chang, MD
498 Vaccination-Associated Renal Disease
Astrid Weins, MD, PhD and Mariam Priya Alexander, MD
502 Nephropathies in Chronic Liver Diesease, Including Hepatic Glomerulosclerosis
Robert B. Colvin, MD
506 Renal Disease in Rheumatoid Arthritis
Neeraja Kambham, MD
512 Hemophagocytic Glomerulopathy
Lynn D. Cornell, MD
516 Coenzyme-Q Nephropathies
Laura Barisoni, MD
520 Intravascular Large B-Cell Lymphoma
Anthony Chang, MD
SECTION 3: VASCULAR DISEASES
524 Overview and Classification of Systemic Vasculitides
Surya V. Seshan, MD and Ingeborg Bajema, MD
ANCA DISEASES
534 ANCA-Related Glomerulonephritis
Surya V. Seshan, MD and Ingeborg Bajema, MD
540 Microscopic Polyangiitis
Surya V. Seshan, MD and Ingeborg Bajema, MD
548 Granulomatosis With Polyangiitis
Surya V. Seshan, MD and Ingeborg Bajema, MD
558 Eosinophilic Granulomatosis With Polyangiitis
(Churg-Strauss)
Surya V. Seshan, MD and Ingeborg Bajema, MD
564 Drug-Induced ANCA Vasculitis
Surya V. Seshan, MD and Ingeborg Bajema, MD
NON-ANCA VASCULITIDES
568 Polyarteritis Nodosa
Surya V. Seshan, MD
574 Kawasaki Disease
Surya V. Seshan, MD and Yael K Heher, MD
576 Giant Cell Arteritis
Surya V. Seshan, MD
580 Takayasu Arteritis
Surya V. Seshan, MD
584 Hypocomplementemic Urticarial Vasculitis (Anti-C1q Vasculitis)
Robert B. Colvin, MD
THROMBOTIC MICROANGIOPATHIES
586 Introduction to Thrombotic Microangiopathies
Neeraja Kambham, MD and Ivy A. Rosales, MD
592 Hemolytic Uremic Syndrome, Infection Related
Neeraja Kambham, MD and Ivy A. Rosales, MD
598 Thrombotic Microangiopathy, Genetic
Neeraja Kambham, MD and Ivy A. Rosales, MD
602 Thrombotic Microangiopathy, Autoimmune
Neeraja Kambham, MD and Ivy A. Rosales, MD
606 Thrombotic Microangiopathy, Drugs
Neeraja Kambham, MD and Ivy A. Rosales, MD
610 Postpartum Hemolytic Uremic Syndrome
Neeraja Kambham, MD and Ivy A. Rosales, MD
614 Scleroderma Renal Disease
Neeraja Kambham, MD and Ivy A. Rosales, MD
620 Multicentric Castleman Disease
Lynn D. Cornell, MD
OTHER DISEASES AFFECTING ENDOTHELIUM
622 Preeclampsia, Eclampsia, HELLP Syndrome
Anthony Chang, MD
624 Radiation Nephropathy
Anthony Chang, MD
626 Sickle Cell Nephropathy
Anthony Chang, MD
630 Retinal Vasculopathy and Cerebral Leukodystrophy
Robert B. Colvin, MD
HYPERTENSIVE RENAL DISEASE
632 Hypertensive Renovascular Disease
A. Brad Farris, III, MD
640 Renal Artery Stenosis
A. Brad Farris, III, MD
644 Fibromuscular Dysplasia
A. Brad Farris, III, MD
650 Neurofibromatosis
Kammi J. Henriksen, MD and Stephen M. Bonsib, MD
THROMBOTIC AND EMBOLIC DISEASE
654 Renal Vein Thrombosis
Anthony Chang, MD and Yael K Heher, MD
656 Renal Artery Thrombosis
Anthony Chang, MD
658 Atheromatous Emboli
Anthony Chang, MD
660 Hydrophilic Polymer Emboli
Kammi J. Henriksen, MD
SECTION 4: TUBULOINTERSTITIAL DISEASES
664 Overview and Classification of Tubulointerstitial Diseases
Robert B. Colvin, MD
666 Differential Diagnosis of Acute Interstitial Nephritis
Lynn D. Cornell, MD
672 Granulomatous Interstitial Nephritis
Ivy A. Rosales, MD
676 Guide to Crystal Nephropathies
ISCHEMIC INJURY
680 Acute Tubular Injury
Shane Meehan, MB, BCh
686 Renal Cortical Necrosis
Shane Meehan, MB, BCh
688 Sepsis/Shock
Joseph P. Gaut, MD, PhD
IMMUNOLOGIC TUBULAR DISEASES
690 IgG4-Related Disease
Lynn D. Cornell, MD
700 Sjögren Syndrome
Josephine M. Ambruzs, MD, MPH
704 Tubulointerstitial Nephritis With Uveitis
A. Brad Farris, III, MD
708 Sarcoidosis
Josephine M. Ambruzs, MD, MPH
712 Antibrush Border Autoantibody Tubulointerstitial Nephritis
Ivy A. Rosales, MD and Robert B. Colvin, MD
714 Anti-Tubular Basement Membrane Disease
Robert B. Colvin, MD
716 Idiopathic Hypocomplementemic Tubulointerstitial Nephritis
Lynn D. Cornell, MD
720 Tubulointerstitial Nephritis With IgM(+) Plasma Cells
Lynn D. Cornell, MD
722 Giant Cell Tubulitis With TBM Deposits
Anthony Chang, MD
MONOCLONAL IMMUNOGLOBULIN DISEASES OF TUBULOINTERSTIITIUM
724 Light Chain Cast Nephropathy
Anthony Chang, MD and Kammi J. Henriksen, MD
730 Light Chain Proximal Tubulopathy With Crystals
Lynn D. Cornell, MD
734 Light Chain Proximal Tubulopathy Without Crystals
Christopher P. Larsen, MD and Tiffany Caza, MD
738 Crystal-Storing Histiocytosis
Mariam Priya Alexander, MD
DRUG-INDUCED TUBULOINTERSTITIAL DISEASES
742 Drug-Induced Acute Interstitial Nephritis
Lynn D. Cornell, MD and Robert B. Colvin, MD
748 Drugs That Cause Tubulointerstitial Nephritis
Robert B. Colvin, MD and Lynn D. Cornell, MD
750 Checkpoint Inhibitor-Induced Kidney Diseases
Ivy A. Rosales, MD
754 Papillary Necrosis
Neeraja Kambham, MD
758 Cisplatin Nephrotoxicity
Shane Meehan, MB, BCh
760 Osmotic Tubulopathy
Shane Meehan, MB, BCh and Evan Farkash, MD, PhD
764 Antiviral Drug Nephrotoxicity
Shane Meehan, MB, BCh
770 Acute Phosphate Nephropathy
Lynn D. Cornell, MD
772 Lithium-Induced Renal Disease
Anthony Chang, MD and Yael K Heher, MD
774 Calcineurin Inhibitor Toxicity
Shane Meehan, MB, BCh
780 mTOR Inhibitor Toxicity
Lynn D. Cornell, MD
782 Vancomycin-Induced Cast Nephropathy
Kammi J. Henriksen, MD
784 Anticoagulant-Related Nephropathy
Christopher P. Larsen, MD and Tiffany Caza, MD
786 Illicit Drugs and Opioids
Kammi J. Henriksen, MD
TOXIC INJRY
788 Myoglobinuria/Rhabdomyolysis/Hemoglobinuria
Neeraja Kambham, MD
790 Bile Cast Nephropathy
Anthony Chang, MD
792 Lead and Other Heavy Metal Toxins
Shane Meehan, MB, BCh
796 Ethylene Glycol Toxicity
Shane Meehan, MB, BCh
798 Aristolochic Acid Nephropathy
Shane Meehan, MB, BCh
800 Balkan Endemic Nephropathy
Shane Meehan, MB, BCh
802 Argyria
Robert B. Colvin, MD
AUTOSOMAL DOMINANT TUBULOINTERSTITIAL KIDNEY DISEASE
804 MUC1-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Joseph P. Gaut, MD, PhD and Helen Liapis, MD
806 UMOD-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Shane Meehan, MB, BCh
808 REN-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Lynn D. Cornell, MD
810 HNF1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Robert B. Colvin, MD and Marie Claire Gubler, MD
GENETIC CRYSTAL DEPOSITION DISEASES
812 Uric Acid Nephropathy/Gout
Shane Meehan, MB, BCh
816 Primary Hyperoxaluria
Shane Meehan, MB, BCh
818 2,8-Dihydroxyadeninuria
Lynn D. Cornell, MD
820 Cystinosis
Joseph P. Gaut, MD, PhD and Helen Liapis, MD
GENETIC TRANSPORT DISEASES
822 Bartter Syndrome
Shane Meehan, MB, BCh
824 Dent Disease
Lynn D. Cornell, MD
826 Oculocerebrorenal Syndrome of Lowe
Josephine M. Ambruzs, MD, MPH
OTHER GENETIC DISEASES AFFECTING TUBULES
828 Mitochondriopathies
Surya V. Seshan, MD and Laura Barisoni, MD
832 Systemic Karyomegaly
Robert B. Colvin, MD
834 Methylmalonic Acidemia
Lynn D. Cornell, MD and Linda Hasadsri, MD, PhD
MISCELLANEOUS TUBULOINTERSTITIAL DISEASES
838 Nephrocalcinosis
Lynn D. Cornell, MD
840 Secondary Oxalosis
Lynn D. Cornell, MD
842 Chronic Interstitial Nephritis in Agricultural
Communities
Lynn D. Cornell, MD
844 Extramedullary Hematopoiesis
Lynn D. Cornell, MD
848 Mastocytosis
R. Neal Smith, MD
SECTION 5: INFECTIONS OF KIDNEY
BACTERIAL INFECTIONS OF KIDNEY
854 Acute Pyelonephritis
Neeraja Kambham, MD
862 Chronic Pyelonephritis
Neeraja Kambham, MD
866 Xanthogranulomatous Pyelonephritis
Neeraja Kambham, MD and Ivy A. Rosales, MD
870 Malakoplakia
Neeraja Kambham, MD
874 Tuberculosis
Neeraja Kambham, MD
876 BCG Granulomatous Interstitial Nephritis
Neeraja Kambham, MD
878 Leprosy
Neeraja Kambham, MD
879 Megalocytic Interstitial Nephritis
Neeraja Kambham, MD
880 Nocardiosis
Neeraja Kambham, MD
882 Leptospirosis
Shane Meehan, MB, BCh
884 Whipple Disease
Carrie L. Phillips, MD
FUNGAL, RICKETTSIAL, AND PARASITIC INFECTIONS OF KIDNEY
886 Mucormycosis
Anthony Chang, MD
888 Candidiasis
Anthony Chang, MD
889 Histoplasmosis
Anthony Chang, MD
890 Coccidioidomycosis
Anthony Chang, MD
891 Blastomycosis
Anthony Chang, MD
892 Paracoccidioidomycosis
Anthony Chang, MD
893 Aspergillosis
Anthony Chang, MD
894 Cryptococcosis
Anthony Chang, MD
895 Microsporidiosis
Robert B. Colvin, MD
896 Rickettsial Infections
Shane Meehan, MB, BCh
898 Toxoplasmosis
Neeraja Kambham, MD
900 Hydatidosis
Stephen M. Bonsib, MD
VIRAL INFECTIONS OF KIDNEY
902 Polyomavirus Nephritis
Anthony Chang, MD and Evan Farkash, MD, PhD
910 Cytomegalovirus Infection
Anthony Chang, MD and R. Neal Smith, MD
912 Adenovirus Infection
Anthony Chang, MD and R. Neal Smith, MD
914 Epstein-Barr Virus Nephritis
Anthony Chang, MD and R. Neal Smith, MD
916 Herpes Simplex Acute Nephritis
Anthony Chang, MD and R. Neal Smith, MD
918 Hantavirus Nephropathy
A. Brad Farris, III, MD
SECTION 6: DEVELOPMENTAL DISEASES
922 Overview of Congenital Anomalies of Kidney and Urinary Tract
Sanjay Jain, MD, PhD
926 Dysplasia/Hypoplasia/Agenesis
Sanjay Jain, MD, PhD
932 Oligomeganephronia
Robert B. Colvin, MD and Yael K Heher, MD
934 Ectopia, Malrotation, Duplication, Fusion, Supernumerary Kidney
Sanjay Jain, MD, PhD
938 Ask-Upmark Kidney
Lynn D. Cornell, MD
940 Renal Tubular Dysgenesis
Stephen M. Bonsib, MD
SECTION 7: CYSTIC DISEASES
946 Overview of Cystic Diseases
Joseph P. Gaut, MD, PhD, Helen Liapis, MD, and Stephen M. Bonsib, MD
CILIOPATHIES
952 Autosomal Dominant Polycystic Kidney Disease
Anthony Chang, MD, Robert B. Colvin, MD, and Yael K Heher, MD
958 Autosomal Recessive Polycystic Kidney Disease
Stephen M. Bonsib, MD
964 Nephronophthisis and Related Ciliopathies
Kerstin Amann, MD, Helen Liapis, MD, and Robert B. Colvin, MD
OTHER GENETIC CYSTIC DISEASES
970 von Hippel-Lindau Disease
Stephen M. Bonsib, MD
976 Tuberous Sclerosis Complex
Christie L. Boils, MD
982 Zellweger Syndrome
Stephen M. Bonsib, MD
MISCELLANEOUS CYSTIC DISEASES
984 Medullary Sponge Kidney
Lynn D. Cornell, MD and Aleksandr Vasilyev, MD, PhD
986 Mixed Epithelial and Stromal Tumor Family
Stephen M. Bonsib, MD
992 Pediatric Cystic Nephroma
Angelica R. Putnam, MD and Carrie L. Phillips, MD
996 Acquired Cystic Disease
Stephen M. Bonsib, MD and Aleksandr Vasilyev, MD, PhD
1000 Simple and Miscellaneous Cysts
Anthony Chang, MD
1002 Renal Lymphangioma/Lymphangiectasia
Stephen M. Bonsib, MD and Aleksandr Vasilyev, MD, PhD
SECTION 8: DISEASES OF COLLECTING SYSTEM
1008 Introduction to Impediments to Urine Flow
Sanjay Jain, MD, PhD
1012 Reflux Nephropathy
Sanjay Jain, MD, PhD
1016 Obstructive Uropathy
Sanjay Jain, MD, PhD
1020 Nephrolithiasis
Shane Meehan, MB, BCh
1026 Loin Pain Hematuria Syndrome
Stephen M. Bonsib, MD and Xin Gu, MD
SECTION 9: DISEASES OF RENAL ALLOGRAFT
1030 Pathologic Classification of Renal Allograft Diseases
Robert B. Colvin, MD
INTRODUCTION
1032 Evaluation of Allograft Kidney
Lynn D. Cornell, MD and Evan Farkash, MD, PhD
1038 Evaluation of Donor Kidney
Lynn D. Cornell, MD and Evan Farkash, MD, PhD
REJECTION
1044 Acute T-Cell-Mediated Rejection
Lynn D. Cornell, MD and Michael Mengel, MD
1056 Chronic T-Cell-Mediated Rejection
Lynn D. Cornell, MD and Michael Mengel, MD
1060 Hyperacute Rejection
Lynn D. Cornell, MD and Michael Mengel, MD
1064 Acute Antibody-Mediated Rejection
Lynn D. Cornell, MD and Michael Mengel, MD
1072 Chronic Antibody-Mediated Rejection
Lynn D. Cornell, MD and Michael Mengel, MD
1084 Transcript Analysis of Renal Transplant Biopsies
Michael Mengel, MD and R. Neal Smith, MD
RECURRENT AND DE NOVO DISEASES
1088 Diseases That Recur in Allografts
Anthony Chang, MD, Lynn D. Cornell, MD, and R. Neal Smith, MD
1094 De Novo Focal Segmental Glomerulosclerosis
Anthony Chang, MD and Astrid Weins, MD, PhD
1096 De Novo Membranous Glomerulonephritis
Anthony Chang, MD
1100 Anti-GBM Disease in Alport Syndrome
Anthony Chang, MD and R. Neal Smith, MD
1102 Engraftment Syndrome/Chimerism Transition Syndrome
A. Brad Farris, III, MD
1104 Late Post-Transplant Histology
Lynn D. Cornell, MD
OTHER ALLOGRAFT DISEASES
1108 Acute Allograft Ischemia
A. Brad Farris, III, MD
1112 Size Mismatch Allograft Injury
Anthony Chang, MD and Yael K Heher, MD
1114 Urine Leak
A. Brad Farris, III, MD
1115 Lymphocele
A. Brad Farris, III, MD
1116 Transplant Renal Artery Stenosis
A. Brad Farris, III, MD
1118 Tranplant Renal Artery or Vein Thrombosis
A. Brad Farris, III, MD
1120 Posttransplant Lymphoproliferative Disease
A. Brad Farris, III, MD
1130 BK Polyomavirus Neoplasia
Evan Farkash, MD, PhD
1132 Protocol Biopsies
Lynn D. Cornell, MD and Evan Farkash, MD, PhD
1136 Accommodation
Lynn D. Cornell, MD
1138 Tolerance
Robert B. Colvin, MD
1142 Kidney Xenografts
Ivy A. Rosales, MD
KIDNEY PATHOLOGY IN RECIPIENTS OF OTHER TRANSPLANTS
1146 Kidney Diseases in Nonrenal Transplant Recipients
Robert B. Colvin, MD
1150 Graft-vs.-Host Glomerulopathies
Anthony Chang, MD and Yael K Heher, MD
SECTION 10: KIDNEY EXAMINATION
1154 Examination of End-Stage Kidney
Shane Meehan, MB, BCh
1160 Examination of Tumor Nephrectomy Specimens for Nonneoplastic Diseases
Kammi J. Henriksen, MD and Stephen M. Bonsib, MD
1164 Evaluation of Transplant Nephrectomy
Shane Meehan, MB, BCh and Evan Farkash, MD, PhD
1168 Evaluation of Autopsy Kidneys
Kammi J. Henriksen, MD and Mariam Priya Alexander,MD
SECTION 11: TECHNIQUES
1174 Kidney Biopsy Reports
Surya V. Seshan, MD, Anthony Chang, MD, and Lynn D. Cornell, MD
1176 Needle Biopsy: Evaluation for Adequacy
Lynn D. Cornell, MD
1180 Artificial Intelligence and Digital Pathology Analysis
of Interstitium Tubules Vessels
A. Brad Farris, III, MD
1184 Evaluation of Fibrosis
A. Brad Farris, III, MD
1188 Image Analysis of Glomerular Disease Measurement of GBM Thickness and Podocyte Effacement
Laura Barisoni, MD
1192 Immunofluorescence on Paraffin Tissue Sections
Nidia Messias, MD
1196 EM Processing From Paraffin Tissue
A. Brad Farris, III, MD
1198 Detection of Autoantigens in Mebranous Nephropathy
Christopher P. Larsen, MD and A. Bernard Collins, BS
1200 Alport Collagen IV Immunofluorescence
Robert B. Colvin, MD and A. Bernard Collins, BS
1202 C4d Immunohistochemistry/Immunofluorescence
Robert B. Colvin, MD and A. Bernard Collins, BS
1206 Polyomavirus Detection in Tissue
Robert B. Colvin, MD
1208 Mass Spectrometry
Sanjeev Sethi, MD and Mariam Priya Alexander, MD
1210 Diagnostic Genetics of Kidney Diseases
Sanjay Jain, MD, PhD and Yasar Caliskan, MD
1214 Quality Analysis in Renal Pathology
Yael K Heher, MD
