Περιγραφή
Bipolar disorder is one of the most common, and disabling, conditions affecting humankind. Each year, millions of individuals struggle with the effects of this illness. Although clinically well recognized for decades, if not centuries, the causes of this condition remain incompletely understood. However, significant technological advances in both neuroimaging and genetic research have revealed clues about the neurophysiological basis of bipolar illness. In this second edition of The Bipolar Brain, leading experts in neuroimaging and genetics discuss recent discoveries in bipolar disorder that identify the structural, functional and chemical brain changes that seem to underlie this condition, as well as the possible genetic causes of these brain events. New technologies such as miRNA, cerebral blood flow, and fMRI are presented. Based upon these discussions, the authors then integrate these diverse considerations to develop a specific neurophysiological model of bipolar disorder. This model provides a resource to guide clinicians as they struggle to understand this illness, as well as a guide for future investigations into the causes of bipolar disorder. With this guide in hand, this book will lead to a new framework for understanding bipolar disorder in order to, ultimately, develop improved therapies for affected individuals and novel strategies to prevent the onset in children at risk for this condition.
- Only integrative book of its kind establishing a neurophysiological model for bipolar disorder, based upon both genetic and neuroimaging findings
- Discusses key technologies used to study psychiatric conditions like miRNA, cerebral blood flow, and fMRI
- Offers scientists specific background and well-defined models to design next areas of investigation
Περιεχόμενα
Preface
Contributors
Chapter 1: Brain Imaging Techniques and their Application to Bipolar Disorder, Caleb M. Adler
Chapter 2: Structural Brain Abnormalities in Bipolar Disorder, Marcella Bellani, Niccolò Zovetti, Marsal Sanches, Koji Matsuo, Jair C. Soares, and Paolo Brambilla
Chapter 3: Functional Brain Imaging in Bipolar Disorder: Activation Studies, Dylan E. Kirsch, Valeria Tretyak, Stephen M. Strakowski, and Elizabeth T.C. Lippard
Chapter 4: Functional Brain Imaging in Bipolar Disorder: Connectivity And Networks, Jennifer E. Siegel- Ramsay and Jorge R.C. Almeida
Chapter 5: Neurochemical and Metabolic Imaging in Bipolar Disorder, Muharrem Burak Baytunca, In Kyoon Lyoo, and Perry F. Renshaw
Chapter 6: Cerebral Blood Flow in Bipolar Disorder: Past Findings and Future Directions, Megan Mio, Mikaela K. Dimick, Simina Toma, Bradley J. MacIntosh, and Benjamin I. Goldstein
Chapter 7: Neuroimaging Studies of Bipolar Disorder in Youth, Manpreet K. Singh and Melissa P. DelBello
Chapter 8: Neuroimaging Differences Between Bipolar and Unipolar Depression, Michele A. Bertocci, Jennifer E. Siegel- Ramsay, Jorge R.C. Almeida, Stephen M. Strakowski, and Mary L. Phillips
Chapter 9: Neuroimaging in Bipolar Disorder and Schizophrenia, Grace Du and Dost Öngür
Chapter 10: Genetic Techniques and Applications to Bipolar Disorder, Yuhua Zhang, Melvin G. McInnis, and Sebastian Zöllner
Chapter 11: General Genetics of Bipolar Disorder, John I. Nurnberger Jr.
Chapter 12: MiRNAs as Predictors of Bipolar Disorder Diagnosis and Treatment Response, Yogesh Dwivedi
Chapter 13: Genetics of Bipolar Disorder and Schizophrenia, Tim B. Bigdeli and Philip D. Harvey
Chapter 14: Mitochondrial Genetics and Bipolar Disorder, Christine Konradi and Tadafumi Kato
Chapter 15: Integration and Consolidation: A Neurophysiological Model of Bipolar Disorder, Stephen M. Strakowski and Gin S. Malhi
Index
