Περιγραφή
Discover the future of medicine in this extensively updated edition of the pioneering textbook, reflecting the rapid progress in the field
Molecular medicine is a rapidly growing field, and the molecular basis of diseases can be used to develop therapeutic approaches in numerous other medical subfields. Research into molecular medicine has been used as the basis for gene therapy, precision medicine, and more. Molecular Medicine provides a fundamental overview of this cutting-edge, interdisciplinary field, incorporating modules from basic immunology to virology to new approaches. Now fully updated to reflect the exponential progress in biomedical research, it promises to put students on the leading edge of a revolution in the life sciences.
Readers of the second edition of Molecular Medicine will also find:
- Detailed discussion of cutting-edge topics including cancer stem cells, mRNA vaccines, organs-on-a-chip, and more
- Professional artwork throughout
- Chapter summaries, exercises, and study questions for each chapter
Molecular Medicine is ideal for graduate students in life sciences and medicine, as well as the lecturers and libraries that support them.
Περιεχόμενα
1 Introduction
1.1 The Basics of Molecular Medicine
1.2 The Human Cell
1.3 DNA Replication and Gene Expression
1.4 Biological Communication
1.5 The Immune System
2 Methods in Molecular Medicine
2.1 DNA Microarrays
2.2 Quantitative Polymerase Chain Reaction
2.3 Next-Generation Sequencing
2.4 Proteomics
2.5 Animal Models in Biomedical Research
2.6 Alternatives to Animal Testing
2.7 Additional Methods
3 Genetic Disorders
3.1 Single-Gene Disorders
3.2 Polygenic Disorders
4 Molecular Oncology
4.1 Basics of Oncology
4.2 Selected Cancer Diseases
4.3 Oncolytic Virus Therapy
4.4 Cancer Stem Cells
4.5 Cancer Immunotherapy
5 Molecular Virology
5.1 The Basics of Virology
5.2 Vaccination
5.3 Detection of Viruses
5.4 Antiviral Therapy
5.5 Prions
6 Bacteria and Eukaryotic Pathogens
6.1 Bacteria
6.2 Eukaryotic Pathogens
7 Genomics and Proteomics
7.1 Whole Genome Sequencing
7.2 The Human Genome
7.3 Sequencing of Ancient DNA
7.4 Follow-up Initiatives of the Human Genome Project
8 Genetic Testing
8.1 Types of Genetic Tests
8.2 Chromosome Abnormalities
8.3 Molecular Diagnosis
9 Pharmacogenetics/Pharmacogenomics
9.1 Uptake and Transport of Drugs
9.2 Drug Metabolism
9.3 Drug Targeting
9.4 Drug Toxicity and Hypersensitivity
9.5 Drug Development and Individual Pharmacotherapy
10 Recombinant Protein Drugs
10.1 Production of Recombinant Proteins
10.2 Classes of Recombinant Drugs
11 Gene Therapy
11.1 Types of Gene Therapy
11.2 Methods of Gene Transfer
11.3 Tissue Speci¿city of Gene Transfer and Gene Expression
11.4 Applications of Gene Therapy
11.5 Genome Editing with CRISPR/Cas
11.6 Future Prospects
12 Stem Cells
12.1 Embryonic Stem Cells
12.2 Adult Stem Cells
12.3 Induced Pluripotent Stem Cells
12.4 Transdifferentiation and Direct Reprogramming
12.5 Differentiation of Stem Cells
12.6 Medical Applications of Stem Cells
13 Oligonucleotide-based Strategies
13.1 Antisense Oligonucleotides
13.2 RNA Interference
13.3 MicroRNAs
13.4 Aptamers, Decoy Oligonucleotides, and Immunostimulatory Oligonucleotides
14 Ethics in Molecular Medicine
14.1 The Basis of Bioethics
14.2 Fields of Application
