Basic Clinical Radiobiology 6th Edition

Preface
About the editors
List of contributors
Glossary

1. Introduction: The significance of radiobiology and radiotherapy for cancer treatment – Michael C. Joiner, Albert J. van der Kogel, and G. Gordon Steel. 2. Irradiation-induced damage and the DNA damage response – Marianne Koritzinsky, Shane M. Harding, Conchita Vens, and Bradly G. Wouters. 3. Cell death after irradiation – how, when and why cells die – Bradly G. Wouters. 4. Quantifying cell kill and cell survival – Michael C. Joiner. 5. Radiation dose-response relationships – Søren M. Bentzen. 6. Linear energy transfer and relative biological effectiveness – Michael C. Joiner and Jay W. Burmeister. 7. Physics of radiation therapy for the radiobiologist – Jay W. Burmeister and Michael C. Joiner. 8. Tumour growth and response to radiation – Daniel Zips. 9. Fractionation: The Linear-Quadratic approach – Michael C. Joiner and Søren M. Bentzen. 10. The linear-quadratic approach in clinical practice – Søren M. Bentzen and Michael C. Joiner. 11. Modified fractionation – Vincent Grégoire, Michael Baumann, and Mechthild Krause. 12. Early effects in epithelial tissues, the role of stem cells and time factors – Robert P. Coppes, †Wolfgang Dörr, Peter van Luijk and Lara Barazzuol. 13. The dose-rate effect – Albert J. van der Kogel and Michael C. Joiner. 14. Pathogenesis of late normal tissue effects – Lara Barazzuol, Peter van Luijk, Robert P. Coppes, Albert J. van der Kogel, and †Wolfgang Dörr. 15. Volume effects, regional responses, and risk models – Peter van Luijk, Robert P. Coppes, †Wolfgang Dörr, and Albert J. van der Kogel. 16. Biological modifiers of normal tissue effects – Robert P. Coppes and †Wolfgang Dörr. 17. The oxygen effect and therapeutic approaches to tumour hypoxia – Michael R. Horsman, J. Martin Brown, Albert J. van der Kogel, Marianne Koritzinsky, Bradly G. Wouters, and Jens Overgaard. 18. The tumour microenvironment and cellular hypoxia responses – Bradly G. Wouters, Marianne Koritzinsky, J. Martin Brown, and Albert J. van der Kogel. 19. Combined radiotherapy and chemotherapy from the perspective of the Radiation Oncologist – Vincent Grégoire, Chiara Gottardi, Jean-Pascal Machiels, and Michael Baumann. 20. Molecular targeted agents for enhancing tumour response – Ina Kurth, Karin Haustermans, Sofie Isebaert, Henning Willers, and Michael Baumann. 21. Biological individualisation of radiotherapy – Catharine M.L. West, Laure Marignol, and Sarah L. Kerns. 22. Molecular image guided radiotherapy – Vincent Grégoire, Olivier Beuf, Cédric Draulans, Karin Haustermans, and John A. Lee. 23. Retreatment tolerance of normal tissues – Dorota Gabryś and †Wolfgang Dörr. 24. Cancer stem cells in radiotherapy – Robert P. Coppes, Michael Baumann, Mechthild Krause, and Richard P. Hill. 25. Hadron therapy: The clinical aspects – Vincent Grégoire, Jay W. Burmeister, Cai Grau, and Michael C. Joiner. 26. Radiation and the immune system – Dörthe Schaue and William H. McBride. 27. Second cancers after radiotherapy – Klaus Rüdiger Trott and David C. Hodgson.

Index