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Brain Neurotrauma Molecular, Neuropsychological, and Rehabilitation Aspects

ISBN: 9781032917719
ISBN: 9781032917719
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Περιγραφή

Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research.

 

The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries.

Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.

Περιεχόμενα

Experimental CNS Trauma: A General Overview of Neurotrauma Research; Jonathan Lifshitz

 

Combat TBI: History, Epidemiology and Injury Modes; Ralph G. DePalma

 

NEUROMECHANISMS IN BRAIN INJURY

 

Development of Concepts in the Pathology of Traumatic Axonal and Traumatic Brain Injury; William L. Maxwell

 

Pathophysiology of Mild TBI: Implications for Altered Signaling Pathways; Robert A. Laskowski, Jennifer A. Creed, and Ramesh Raghupathi

 

Oxidative Stress, Brain-Edema, Blood-Brain Barrier Permeability and Autonomic Dysfunction from Traumatic Brain Injury; Hale Zerrin Toklu and Nihal Tümer

 

The Contributing Role of Lipid Peroxidation and Protein Oxidation in the Course of CNS Injury Neurodegeneration and Neuroprotection: An Overview; Edward D. Hall

 

IGF-1/IGF-R Signaling in Traumatic Brain Injury: Impact on Cell Survival, Neurogenesis, and Behavioral Outcome; Sindhu K. Madathil and Kathryn E. Saatman

 

Microglia in Experimental Brain Injury: Implications on Neuronal Injury and Circuit Remodeling; Megan N. Evilsizor, Helen F. Ray-Jones, Timothy W. Ellis, Jr., Jonathan Lifshitz, and Jenna M. Ziebell

 

Evaluating the Effects of APOE4 after Mild Traumatic Brain Injury in Experimental Models; Rebekah Mannix and William P. Meehan III

 

The Cytoprotective role of Prostaglandin D2 DP1 Receptor Against Neuronal Injury Following Acute Excitotoxicity and Cerebral Ischemia; Sylvain Doré and Abdullah Shafique Ahmad

 

MANAGEMENT IN CNS TRAUMA

 

Chronic Pain in Neurotrauma: Implications on Spinal Cord and Traumatic Brain Injury; Rabih A. Moshourab, Michael Schäfer, and Elie D. Al-Chaer

 

Nonconvulsive Seizures as Secondary Insults in Experimental Traumatic Brain Injury; Laura Stone McGuire, Amade Bregy, Justin Sick, W. Dalton Dietrich, Helen M. Bramlett, and Thomas Sick

 

Characterization and Management of Headache after Mild Traumatic Brain Injury; Sylvia Lucas

 

Traumatic Brain Injury (TBI)-Induced Spasticity: Neurobiology, Treatment, and Rehabilitation; Prodip Bose, Jiamei Hou, and Floyd J. Thompson

 

MODELING BRAIN INJURY

 

Techniques and Methods of Animal Brain Surgery: Perfusion, Brain Removal, and Histological Techniques; Jihane Soueid, Amaly Nokkari, and Joelle Makoukji

 

Controlled Cortical Impact Model; Nicole D. Osier, Jonathan R. Korpon, and C. Edward Dixon

 

A Two-Model Approach to Investigate the Mechanisms Underlying Blast-Induced Traumatic Brain Injury; Haoxing Chen, Shlomi Constantini, and Yun Chen

 

Acute Pathophysiology of Blast Injury: From Biomechanics to Experiments and Computations: Implications on Head and Polytrauma; Namas Chandra and Aravind Sundaramurthy

 

Modeling Fluid Percussion Injury: Relevance to Human Traumatic Brain Injury; Katharine Eakin, Rachel Rowe, and Jonathan Lifshitz

 

IMAGING AND BIOMARKERS

 

CNS Trauma Biomarkers and Surrogate Endpoints Pipeline from Bench to Bedside: A Translational Perspective; Tarek H. Mouhieddine, Leeanna El Houjeiri, Mirna Sabra, Ronald Hayes, and Stefania Mondello

 

The Use and Potential of pNF-H as a General Blood Biomarker of Axonal Loss: An Immediate Application for CNS Injury; Gerry Shaw

 

Exploring Serum Biomarkers for Mild Traumatic Brain Injury; Linda Papa, Damyan Edwards, and Michelle Ramia

 

Modeling the Neurobehavioral Consequences of Blast-Induced Traumatic Brain Injury Spectrum Disorder and Identifying Related Biomarkers; Denes V. Agoston and Alaa Kamnaksh

 

Magnetic Resonance Imaging Application in the Area of Mild and Acute Traumatic Brain Injury: Implication for Diagnostic Marker; Arnold Toth

 

Translational Metabolomics of Head Injury: Exploring Dysfunctional Cerebral Metabolism with ex Vivo NMR Spectroscopy-Based Metabolite Quantification; Stephanie M. Wolahan, Daniel Hirt, and Thomas C. Glenn

 

The Emerging Impact of microRNAs in Neurotrauma Pathophysiology and Therapy; Oneil G. Bhalala

 

Neuroproteome Dynamics in Modeled Brain Injury: A Systems Neurobiology Perspective; Pavel Lizhnyak, Hiyab Yohannes, and Andrew K. Ottens

 

Gene Interaction Hierarchy Analysis can be an Effective Tool for Managing Big Data Related to Unilateral Traumatic Brain Injury; Todd E. White and Byron D. Ford

 

Autoantibodies in CNS Trauma and Neuropsychiatric Disorders: A New Generation of Biomarkers; Firas Kobeissy and Rabih A. Moshourab

 

Systems Biology Application to Decipher Mechanisms and Novel Biomarkers in CNS Trauma; Chenggang Yu and Firas Kobeissy

 

NEUROCOGNITIVE AND NEUROBEHAVIORAL TOPICS IN BRAIN INJURY

 

Neuropathology of Mild Traumatic Brain Injury: Correlation to Neurocognitive and Neurobehavioral Findings; Erin D. Bigler

 

Blast-Related Mild Traumatic Brain Injury: Neuropsychological Evaluation and Findings; Nathaniel W. Nelson, Nicholas D. Davenport, and Scott R. Sponheim

 

Persistent Cognitive Deficits: Implications of Altered Dopamine in Traumatic Brain Injury; Hong Qu Yan, Nicole D. Osier, Jonathan Korpon, James W. Bales, Anthony E. Kline, Amy K. Wagner, and C. Edward Dixon

 

NEUROREHABILITATION AND NEUROPROTECTION

 

Rehabilitative Paradigms after Experimental Brain Injury: Relevance to Human Neurotrauma; Corina O. Bondi, Roya Tehranian-DePasquale, Jeffrey P. Cheng, Christina M. Monaco, Grace S. Griesbach, and Anthony E. Kline

 

Models of Posttraumatic Brain Injury Neurorehabilitation; Michelle D. Failla and Amy K. Wagner

 

Translational Considerations for Behavioral Impairment and Rehabilitation Strategies after Diffuse Traumatic Brain Injury; Theresa Currier Thomas, Taylor A. Colburn, Kelsey Korp, Aida Khodadad, and Jonathan Lifshitz

 

Endothelin, Cerebral Blood Flow, and Traumatic Brain Injury: Implications for a Future Therapeutic Target; Justin C. Graves and Christian W. Kreipke,

 

Application of Novel Therapeutic Agents for CNS Injury: NAAG Peptidase Inhibitors; Bruce G. Lyeth

 

Neuregulin-1 and Neurovascular Protection; Limin Wu, Samantha J. Walas, Wendy Leung, Eng H. Lo, and Josephine Lok

 

Potential Use of Calpain Inhibitors as Brain Injury Therapy; Emilio B. Cagmat, Joy D. Guingab-Cagmat, A.V. Vakulenko, R.L. Hayes, and John Anagli

 

Nanoparticles for Neurotherapeutic Drug Delivery in Neurodegenerative Disorders: Application in Neurotrauma; Mark S. Kindy and Alexey Vertegel

 

Stem Cell Therapy in Brain Trauma: Implications for Repair and Regeneration of Injured Brain in Experimental TBI Models; Andrew Rolfe and Dong Sun

 

Cortical Stimulation-Induced Structural Plasticity and Functional Recovery after Brain Damage; DeAnna L. Adkins

 

Cranial Nerve Noninvasive Neuromodulation: New Approach to Neurorehabilitation; Yuri Danilov, Kurt Kaczmarek, Kimberly Skinner, and Mitchell Tyler

 

MILD BRAIN INJURY AND SPORT CONCUSSION

 

Blast Injuries and Blast-Induced Neurotrauma Overview of Pathophysiology and Experimental Knowledge: Models and Findings; Ibolja Cernak

 

Animal Models for Concussion: Molecular and Cognitive Assessments—Relevance to Sport and Military Concussions; Hayde Bolouri and Henrik Zetterberg

 

The Problem of Neurodegeneration in Cumulative Sports Concussions: Emphasis on

 

Neurofibrillary Tangle Formation; Vassilis E. Koliatsos and Leyan Xu

 

SUBSTANCE ABUSE AND COMORBID CONDITIONS

 

Evidence for Beneficial and Adverse Effects of Alcohol in Animal Models and Clinical Studies of Traumatic Brain Injury; Anna N. Taylor and Richard L. Sutton

 

Modeling TBI-Induced Alterations in Alcohol Use Behaviors; James P. Caruso, Jennifer L. Lowing, and Alana C. Conti

 

Index