Περιεχόμενα
VOLUME I
Part 1: Structure and Function of Bone, Joints, and Connective Tissue
1. Biology of the Normal Joint, 1
Carla R. Scanzello and Steven R. Goldring
2. Synovium, 20
Douglas J. Veale and Gary S. Firestein
3. Cartilage and Chondrocytes, 34
Ali Mobasheri, Mary B. Goldring, and Richard F. Loeser
4. Biology, Physiology, and Morphology of Bone, 60
Aline Bozec, Anika Grüneboom, and Georg Schett
5. Muscle: Anatomy, Physiology, and Biochemistry, 67
Mark S. Miller, Edward P. Debold, and Michael J. Toth
6. Biomechanics, 80
Kenton R. Kaufman and KaiNan An
7. Regenerative Medicine and Tissue Engineering, 92
Frank P. Luyten, Cosimo De Bari, and Francesco DellAccio
8. Proteinases and Matrix Degradation, 109
Yoshifumi Itoh
Part 2: Cells Involved in Autoimmune Diseases and Inflammation
9. Dendritic Cells, 132
Mansi Saxena, Nicolas Vabret, Luciana Ribeiro Muniz, and Nina Bhardwaj
10. Mononuclear Phagocytes, 149
Deborah R. Winter, Anna Montgomery, and Harris Perlman
11. Neutrophils, 161
Binita Shah, Nathalie Burg, and Michael H. Pillinger
12. T Lymphocytes, 182
Ralph C. Budd
13. B Cells, 199
Yong-Rui Zou, Christine Grimaldi, and Betty Diamond
14. Fibroblasts and Fibroblast-like Synoviocytes, 222
Christopher D. Buckley and Andrew Filer
15. Mast Cells, 241
Peter A. Nigrovic
16. Innate Lymphoid Cells and Natural Killer Cells, 254
Michael A. Paley and Wayne M. Yokoyama
17. Platelets and Megakaryocytes, 262
Eric Boilard and Peter A. Nigrovic
Part 3: Effector Mechanisms in Autoimmunity and Inflammation
18. Principles of Signaling, 273
Abel Suarez-Fueyo, Vaishali R. Moulton, and George C. Tsokos
19. The Immunologic Repercussions of Cell Death, 286
Helen M. Beere and Douglas R. Green
20. Innate Immunity, 306
Gregoire Lauvau and Steven A. Porcelli
21. Adaptive Immunity, 320
Martha S. Jordan and Gary A. Koretzky
22. Autoimmunity and Tolerance, 337
Dwight H. Kono and Argyrios N. Theofilopoulos
23. The Microbiome in Health and Disease, 355
Rob Knight
24. Metabolic Regulation of Immunity, 368
Ruoning Wang, Tingting Wang, and Stephen Tait
25. Genetics of Rheumatic Diseases, 378
Stephen Eyre and Anne Barton
26. Epigenetics of Rheumatic Diseases, 393
Amr H. Sawalha and Matlock A. Jeffries
27. Complement System, 409
V. Michael Holers and Leendert A. Trouw
28. Prostaglandins, Leukotrienes, and Related Compounds, 420
Robert B. Zurier
29. Chemokines and Cellular Recruitment, 437
Gerard Graham
30. Angiogenesis, 445
Ursula Fearon, Zoltán Szekanecz, and Douglas J. Veale
31. Cytokines, 455
Iain B. McInnes
32. Experimental Models for Rheumatoid Arthritis, 467
Rikard Holmdahl
33. Neuronal Regulation of Pain and Inflammation, 480
Camilla I. Svensson and Linda S. Sorkin
Part 4: Broad Issues in the Approach to Rheumatic Disease
34. Clinical Research Methods in Rheumatic Disease, 495
Jeffrey R. Curtis, Yvonne M. Golightly, and Kenneth G. Saag
35. Economic Impact of Arthritis and Rheumatic Conditions, 510
Louise B. Murphy
36. Assessment of Health Outcomes, 522
Dorcas E. Beaton, Maarten Boers, Peter Tugwell, and Lara Maxwell
37. Biomarkers in Rheumatology, 536
Michael J. Townsend, Saloumeh K. Fischer, and Andrew C. Chan
38. Occupational and Recreational Musculoskeletal Disorders, 551
Richard S. Panush
39. Cardiovascular Risk in Inflammatory Rheumatic Disease, 563
Cynthia S. Crowson, Sherine E. Gabriel, and Anne Grete Semb
40. Cancer Risk in Rheumatic Diseases, 579
Eric L. Matteson
41. Introduction to Physical Medicine and Rehabilitation, 592
Sara J. Cuccurullo, Jaclyn Joki, and Ofure Luke
42. Pregnancy and Rheumatic Diseases, 604
Lisa R. Sammaritano and Bonnie L. Bermas
Part 5: Evaluation of Generalized and Localized Symptoms
43. History and Physical Examination of the Musculoskeletal System, 621
John M. Davis III, Kevin G. Moder, and Gene G. Hunder
44. Ultrasound in Rheumatology, 638
Eugene Y. Kissin, Paul J. DeMarco, and Amy C. Cannella
45. Evaluation of Monoarticular and Polyarticular Arthritis, 663
Ronald F. van Vollenhoven
46. Skin and Rheumatic Diseases, 678
David F. Fiorentino and Victoria P. Werth
47. The Eye and Rheumatic Diseases, 702
James T. Rosenbaum
Part 6: Differential Diagnosis of Regional and Diffuse Musculoskeletal Pain
48. Neck Pain, 711
Jennifer Kosty, Rani Nasser, Raul A. Vasquez, Cyrus C. Wong, and Joseph S. Cheng
49. Shoulder Pain, 727
Scott David Martin and Thomas S. Thornhill
50. Low Back Pain, 753
Rajiv Dixit
51. Hip and Knee Pain, 776
James I. Huddleston, III, and Stuart Goodman
52. Foot and Ankle Pain, 792
Christopher P. Chiodo, Mark D. Price, and Adam P. Sangeorzan
53. Hand and Wrist Pain, 800
Kenneth W. Donohue, Felicity G. Fishman, and Carrie R. Swigart
54. Temporomandibular Joint Pain, 813
Daniel M. Laskin
55. Fibromyalgia, 825
Leslie J. Crofford
Part 7: Diagnostic Tests and Procedures in Rheumatic Diseases
56. Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology, 841
Hani S. El-Gabalawy and Stacy Tanner
57. Arthrocentesis and Injection of Joints and Soft Tissues, 859
Ahmed S. Zayat, Andrea di Matteo, and Richard J. Wakefield
58. Anti-nuclear Antibodies, 875
Stanford L. Peng and Joseph E. Craft
59. Autoantibodies in Rheumatoid Arthritis, 890
Erika Darrah, Antony Rosen, and Felipe Andrade
60. Acute Phase Reactants, 907
Rebecca Haberman, Cesar E. Fors Nieves, Bruce N. Cronstein, and Amit Saxena
61.Imaging in Rheumatic Diseases, 920
Mikkel Østergaard, Ho Jen, Jacob L. Jaremko, and Robert G.W. Lambert
Part 8: Pharmacology of Anti-rheumatic Drugs
62. Therapeutic Targeting of Prostanoids, 965
Leslie J. Crofford
63. Glucocorticoid Therapy, 985
Marlies C. van der Goes and Johannes W.G. Jacobs
64. Traditional DMARDs: Methotrexate, Lefl, Sulfasalazine, Hydroxychloroquine, and Combination Therapies, 1007
Amy C. Cannella and James R. ODell
65. Immunosuppressive Drugs, 1031
Jacob M. van Laar
66. Anti-cytokine Therapies, 1046
Katharine McCarthy, Arthur Kavanaugh, and Christopher T. Ritchlin
67. Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics, 1068
Peter C. Taylor
68. Intra-cellular Targeting Agents in Rheumatic Disease, 1091
Virginia Reddy and Stanley Cohen
69. Urate-Lowering Therapy, 1111
Ted R. Mikuls
70. Bisphosphonates, 1125
Arthur C. Santora II and Kenneth G. Saag
71. Analgesic Agents in Rheumatic Disease, 1135
Gregory R. Polston and Mark S. Wallace
72. Nutrition and Rheumatic Diseases, 1156
Lisa K. Stamp and Leslie G. Cleland
73. Evaluation and Management of Early Undifferentiated Arthritis, 1173
Karim Raza
VOLUME II
Part 9: Rheumatoid Arthritis
74. Etiology of Rheumatoid Arthritis, 1181
Gary S. Firestein
75. Pathogenesis of Rheumatoid Arthritis, 1200
Gary S. Firestein
76. Clinical Features of Rheumatoid Arthritis, 1236
Bryant R. England and Ted R. Mikuls
77. Treatment of Rheumatoid Arthritis, 1258
James R. ODell
78. Sjögrens Syndrome, 1284
E. William St. Clair and David L. Leverenz
Part 10: Spondyloarthritis
79. Etiology and Pathogenesis of Spondyloarthritis, 1307
Keith A. Sikora and Robert A. Colbert
80. Ankylosing Spondylitis and Other Forms of Axial Spondyloarthritis, 1319
Sjef van der Linden, Matthew Brown, Lianne S. Gensler, Tony Kenna, Walter P. Maksymowych, and William J. Taylor
81. Reactive Arthritis, 1344
John D. Carter and Alan P. Hudson
82. Psoriatic Arthritis, 1359
Oliver FitzGerald and Conor Magee
83. Inflammatory Bowel Disease-Associated Arthritis and Other Enteropathic Arthropathies, 1381
Richard Zamore, Meenakshi Bewtra, and Alexis Ogdie
Part 11: Systemic Lupus Erythematosus and Related Syndromes
84. Etiology and Pathogenesis of Systemic Lupus Erythematosus, 1396
Mary K. Crow
85. Clinical Features of Systemic Lupus Erythematosus, 1413
Maria DallEra and David Wofsy
86. Treatment of Systemic Lupus Erythematosus, 1437
Antonis Fanouriakis, George Bertsias, and Dimitrios T. Boumpas
87. Antiphospholipid Syndrome, 1460
Medha Barbhaiya, Jane E. Salmon, and Doruk Erkan
Part 12: Systemic Sclerosis, Inflammatory Myopathies, and Overlap Syndromes
88. Etiology and Pathogenesis of Systemic Sclerosis, 1473
John Varga
89. Clinical Features and Treatment of Scleroderma, 1499
Fredrick M. Wigley and Francesco Boin
90. Inflammatory Diseases of Muscle and Other Myopathies, 1539
Kanneboyina Nagaraju, Rohit Aggarwal, and Ingrid E. Lundberg
91. Overlap Syndromes, 1569
Jonathan Graf
Part 13: Vasculitis
92. Classification and Epidemiology of Systemic Vasculitis, 1584
Rennie L. Rhee and Peter A. Merkel
93. Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasus Arteritis, 1595
David B. Hellmann
94. Anti-neutrophil Cytoplasmic Antibody- Associated Vasculitis, 1617
Sharon A. Chung and Paul A. Monach
95. Polyarteritis Nodosa and Related Disorders, 1634
Raashid Luqmani and Abid Awisat
96. Immune Complex-Mediated Small Vessel Vasculitis, 1649
John H. Stone
97. Primary Angiitis of the Central Nervous System, 1659
Rula A. Hajj-Ali and Carol A. Langford
98. Behçets Disease, 1666
Christine S. Ahn, Lindsay C. Strowd, and Joseph L. Jorizzo
Part 14: Crystal-Induced and Inflammasome- Mediated Inflammation
99. Pathogenesis of Inflammasome-Mediated Diseases, 1676
Hal M. Hoffman and Lori Broderick
100. Etiology and Pathogenesis of Hyperuricemia and Gout, 1687
Robert T. Keenan, Michael Toprover, and Michael H. Pillinger
101. Clinical Features and Treatment of Gout, 1710
Nicola Dalbeth
102. Calcium Crystal Disease: Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate, 1732
Robert Terkeltaub
103. Familial Autoinflammatory Syndromes, 1752
Catharina M. Mulders-Manders, Anna Simon, and Jos W.M. van der Meer
Part 15: Cartilage, Bone, and Heritable Connective Tissue Disorders
104. Pathogenesis of Osteoarthritis, 1770
Paul E. Di Cesare, Dominik R. Haudenschild, Steven B. Abramson, and Jonathan Samuels
105. Clinical Features of Osteoarthritis, 1789
Amanda E. Nelson
106. Treatment of Osteoarthritis, 1803
Devyani Misra, Deepak Kumar, and Tuhina Neogi
107. Metabolic Bone Disease, 1819
Nancy E. Lane
108. Proliferative Bone Diseases, 1839
Reuven Mader
109. Osteonecrosis, 1852
Christopher Chang, Adam Greenspan, and M. Eric Gershwin
110. Relapsing Polychondritis, 1876
Gaye Cunnane
111. Heritable Diseases of Connective Tissue, 1886
Deborah Krakow
Part 16: Rheumatic Diseases of Childhood
112. Etiology and Pathogenesis of Juvenile Idiopathic Arthritis, 1905
Edward M. Behrens
113. Clinical Features and Treatment of Juvenile Idiopathic Arthritis, 1911
Joyce J. Hsu, Tzielan C. Lee, and Christy I. Sandborg
114. Childhood-Onset Systemic Lupus Erythematosus, Drug-Induced Lupus in Children, and Neonatal Lupus, 1931
Stacy P. Ardoin and Fatima Barbar-Smiley
115.Juvenile Dermatomyositis, Scleroderma, Vasculitis, and Autoimmune Brain Disease, 1942
Angela B. Robinson, Jeffrey Dvergsten, Kathryn S. Torok, Heather Van Mater, William Gallentine, and Ann M. Reed
Part 17: Infection and Arthritis
116. Bacterial Arthritis, 1979
Paul P. Cook and Dawd S. Siraj
117. Lyme Disease, 1994
Linda K. Bockenstedt
118. Mycobacterial Infections of Bones and Joints, 2009
Eric M. Ruderman and John P. Flaherty
119. Fungal Infections of Bones and Joints, 2022
Eric M. Ruderman and John P. Flaherty
120. Rheumatic Manifestations of HIV Infection, 2033
Jonathan Dau and John D. Reveille
121. Viral Arthritis, 2048
Philippe Gasque and Xavier Guillot
122. Rheumatic Fever and Post-streptococcal Arthritis, 2061
Luiza Guilherme, Pedro Ming Azevedo, and Jorge Kalil
Part 18: Arthritis Accompanying Systemic Disease
123. Amyloidosis, 2077
Helen J. Lachmann and Faye A. Sharpley
124. Sarcoidosis, 2088
Peter Korsten, Nadera J. Sweiss, and Robert P. Baughman
125. Hemochromatosis, 2105
Gaye Cunnane
126. Hemophilic Arthropathy, 2115
Astrid E. Pulles, Lize F. D. van Vulpen, and Floris P.J.G. Lafeber
127. Rheumatic Manifestations of Hemoglobinopathies, 2127
Carlos J. Lozada and Elaine C. Tozman
128. IgG4-Related Disease, 2135
John H. Stone and Shiv Pillai
129. Arthritis Accompanying Endocrine and Metabolic Disorders, 2149
Sebastian E. Sattui and Joseph A. Markenson
130. Rheumatic Paraneoplastic Syndromes-Links Between Malignancy and Autoimmunity, 2161
Bernhard Manger and Georg Schett
131. Tumors and Tumor-like Lesions of Joints and Related Structures, 2167
Darcy A. Kerr and Andrew E. Rosenberg
132. Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer, 2189
Laura C. Cappelli, Clifton O. Bingham III, and Ami A. Shah
Index, I-1
