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Gastrointestinal and Liver Pathology, 3rd Edition. A Volume in the Series: Foundations in Diagnostic Pathology

John R. Goldblum, Amitabh Srivastava, Daniela S. Allende
ISBN: 9780323527941
ISBN: 9780323527941
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Now fully revised to include recent advances in the field, the third edition of Gastrointestinal and Liver Pathology Pathology, a volume in the Foundations in Diagnostic Pathology series, is an essential foundation text for residents and pathologists. The popular template format makes it easy to use, and new information throughout brings you up to date with what’s new in the field, including advances in molecular diagnostic testing and new diagnostic biomarkers. Practical and affordable, this resource is ideal for study and review as well as everyday clinical practice.
Key Features

Key features of this practical text include:

  • A consistent, user-friendly format that explores each entity’s clinical features, gross and microscopic findings, ancillary studies, differential diagnoses, and prognostic and therapeutic considerations.
  • A focus on specific features of selected neoplastic and non-neoplastic entities, including broad and in-depth differential diagnoses.
  • Clinical information on treatment and prognosis, enabling you to better understand the clinical implications of the diagnosis.
  • Nearly 1,000 full-color, high-quality illustrations with extensive figure legends, as well as abundant boxes and tables throughout.
  • Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

 

What’s NEW in this edition:

  • Advances in molecular diagnostic testing and its capabilities and limitations, including targeted/personalized medicine.
  • New diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities.
  • The latest TNM staging and WHO classification systems.
  • New co-editors Drs. Amitabh Srivastava and Daniela S. Allende lead a team of expert, internationally recognized pathologists who keep you up to date with the latest information in the field.
Author Information
By Amitabh Srivastava, MD, Assistant Professor, Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH and Daniela S. Allende, MD, Department of Pathology, Cleveland Clinic, Cleveland, Ohio

Περιεχόμενα

Cover image
Title page
Table of Contents
Any screen, Any time, Anywhere
Copyright
Dedication
Contributors
Foreword
Preface
Acknowledgments
1. Non-Neoplastic Disorders of the Esophagus
Abstract
Esophagitis
Eosinophilic Esophagitis
Lymphocytic Esophagitis
Lichen Planus and Lichenoid Esophagitis
Crohn’s Disease
Graft-Versus-Host Disease
IgG4-Related Esophageal Disease
Therapy or Toxin-Related Injur
Radiation or Chemotherapy Esophagitis
Pill Esophagitis
Esophagitis Dissecans Superficialis or Sloughing Esophagitis
Caustic Esophageal Injury
Miscellaneous Lesions
Inlet Patch
Heterotopic Sebaceous Glands
Glycogenic Acanthosis
Esophageal Hyperkeratosis and Epidermoid Metaplasia
Inflammation and Intestinal Metaplasia of the Gastroesophageal Junction
Structural Abnormalities
Acquired (Diverticula, Webs, and Rings)
Motility Disorders
Systemic Sclerosis
Esophageal Varices, Perforations, and Tears
References
2. Tumors of the Esophagus
Abstract
Squamous Papillomas
Atypical Lipomatous Tumor (“Giant Fibrovascular Polyp” of the Esophagus)
Ancillary Studies
Barrett’s Esophagus
Risk Factors for Esophageal Carcinoma
Dysplasia in Barrett’s Esophagus
Intramucosal Adenocarcinoma
Adenocarcinoma
Squamous Dysplasia and Squamous Cell Carcinoma
Undifferentiated Carcinoma
Pathologic Findings
Microscopic Findings
Ancillary Studies
Salivary Gland Type Tumors
Pathologic Features
Ancillary Studies
Differential Diagnosis
Neuroendocrine Neoplasms
Pathologic Features
Ancillary Studies
Secondary Tumors of the Esophagus
Suggested Readings
3. Non-Neoplastic Disorders of the Stomach
Abstract
Acute Erosive/Hemorrhagic Gastritis (“Stress” Gastritis)
Clinical Features
Reactive (Chemical) Gastropathy
Clinical Features
Helicobacter pylori Gastritis
Clinical Features
Gastric Peptic Ulcer Disease
Clinical Features
Autoimmune Gastritis
Clinical Features
Granulomatous Gastritis
Gastric Crohn’s Disease
Gastric Sarcoidosis
Lymphocytic Gastritis
Clinical Features
Infectious Gastritis
Eosinophilic Gastritis
Clinical Features
Collagenous Gastritis
Clinical Features
Gastric Mucosal Calcinosis
Clinical Features
Doxycycline Gastritis
Clinical Features
Ménétrier’s Disease
Clinical Features
Zollinger-Ellison Syndrome
Clinical Features
Gastric Amyloidosis
Clinical Features
Gastric Antral Vascular Ectasia (“Watermelon Stomach”)
Clinical Features
Portal Hypertensive Gastropathy
Clinical Features
Dieulafoy’s Lesion (Caliber Persistent Artery)
Clinical Features
Suggested Readings
4. Epithelial Polyps and Neoplasms of the Stomach
Abstract
Gastric Polyps
Fundic Gland Polyps
Gastric Hyperplastic Polyps
Gastritis Cystica Polyposa
Pancreatic Heterotopia
Gastric Mucosal Xanthoma
Gastric Carcinomas, Neuroendocrine Tumors, and their Precursor Lesions
Gastric Epithelial Dysplasia and Gastric Adenomas
Pyloric Gland Adenoma
Oxyntic Gland Adenoma
Gastric Adenocarcinoma
Neuroendocrine Neoplasms
Suggested Readings
5. Non-Neoplastic and Inflammatory Disorders of the Small Bowel
Abstract
Patterns of Small Bowel Disorders
Malabsorption Disorders
Celiac Disease
Pathogenesis
Nonresponsive or Refractory Celiac Disease
Collagenous Sprue
Tropical Sprue
Peptic Duodenal Disease
Small Intestinal Bacterial Overgrowth
Nonsteroidal Antiinflammatory Drug–Associated Injury
Olmesartan-Associated Sprue-Like Enteropathy
Common Variable Immunodeficiency
Autoimmune Enteropathy
Microvillus Inclusion Disease
Congenital Tufting Enteropathy (Intestinal Dysplasia)
Enteroendocrine Cell Dysgenesis
Abetalipoproteinemia
Small Intestinal Inflammatory Bowel Disease
Crohn’s Disease
Pathologic Features
Graft-Versus-Host Disease
Pathologic Features
Eosinophilic Gastroenteritis
Pathologic Features
Ischemic or Hemorrhagic Enteritis
Infectious Enteritis
Primary Lymphangiectasia
Incidental Pigmentation
References
Suggested Readings
6. Neoplasms of the Small Intestine
Abstract
Brunner’s Gland Hyperplasia and Hamartoma
Gastric Heterotopia
Pancreatic Heterotopia
Pyloric Gland Adenoma
Conventional Adenoma, Serrated Polyps, and Adenocarcinoma of the Small Intestine
Adenoma and Adenocarcinoma of the Ampulla of Vater
Neuroendocrine Tumors of the Small Intestine
Gangliocytic Paraganglioma
Neuroendocrine Carcinoma of the Small Intestine and Ampulla
Secondary Tumors
Suggested Readings
7. Gastrointestinal Mesenchymal Tumors
Abstract
Gastrointestinal Stromal Tumor
Smooth Muscle Tumors of the Gastrointestinal Tract
Granular Cell Tumor
Clear Cell Sarcoma-Like Tumor of the Gastrointestinal Tract/Malignant Gastrointestinal Neuroectodermal Tumor
Inflammatory Fibroid Polyp
Plexiform Fibromyxoma
Calcifying Fibrous Tumor
Schwannoma of the Gastrointestinal Tract
Mucosal Perineurioma (“Benign Fibroblastic Polyp”)
Mucosal Schwann Cell Hamartoma
Ganglioneuroma
Gangliocytic Paraganglioma
Glomus Tumor
Intraabdominal Desmoid Fibromatosis
Sclerosing Mesenteritis
Inflammatory Myofibroblastic Tumor
Lymphangioma
PEComa
Suggested Readings
8. Non-Neoplastic and Neoplastic Disorders of the Appendix
Abstract
Congenital and Acquired Anatomic Anomalies of the Appendix
Fibrous Obliteration of the Appendiceal Lumen (Neural Hyperplasia)
Acute Appendicitis
Periappendicitis
Ulcerative Colitis Involving the Appendix
Crohn’s Disease Involving the Appendix
Granulomatous Appendicitis
Cystic Fibrosis
Infectious Causes of Acute Appendicitis
Endometriosis, Deciduosis, Gliomatosis
Epithelial Neoplasms of the Appendix (Nonendocrine)
Adenoma
Serrated Polyps
Clinical Features
Low-And High-Grade Appendiceal Mucinous Neoplasms
Clinical Features
Clinical Features
Neuroendocrine Tumors of the Appendix
Clinical Features
Goblet Cell Adenocarcinoma
Clinical Features
Suggested Readings
9. Infectious Diseases of the Gastrointestinal Tract
Abstract
Viral Infections
Cytomegalovirus
Clinical Features
Herpesvirus
Adenovirus
Clinical Features
Human Immunodeficiency Virus–Associated Ulcerative Esophagitis
Aids Enterocolopathy
Bacterial Infections
Sarcina Ventriculi and Related Organisms
Tropheryma Whipplei (Whipple Disease)
Clinical Features
Bacterial Enterocolitis
Escherichia Coli
Enterohemorrhagic Escherichia Coli
Clinical Features
Salmonellosis
Clinical Features
Shigellosis
Clinical Features
CampylobacterSPP.
Clinical Features
Yersiniosis
Clinical Features
Vibrio Cholerae and Related Organisms
Clinical Features
AeromonasSpp.
Clinical Features
Clostridial Infections of the Gut
Clinical Features
Klebsiella Oxytoca
Mycobacterial Infections of the Gut
Clinical Features
Syphilis (Treponema Pallidum)
Clinical Features
Chlamydia Trachomatis
Neisseria Gonorrheae
Intestinal Spirochetosis
Clinical Features
Actinomycosis
Fungal Infections
Prognosis and Therapy
CANDIDASPP.
AspergillusSpp.
Mucormycosis and Related Infections
Clinical Features
Basidiobolus Ranarum
Clinical Features
Histoplasmosis
Penicillium Marneffei
CryptococcusSpp.
Parasitic Infections Of The Gastrointestinal Tract
Clinical Features
Trypanosoma Cruzi (Chagas Disease)
Flagellates
Clinical Features
Visceral Leishmaniasis (Kala-Azar) Caused By Leishmania Donovani and Related Species
Clinical Features
Coccidians and Related Organisms
Clinical Features
Helminths (Nematodes, Trematodes, and Cestodes)
Nematodes
Clinical Features
Ascaris Lumbricoides (Roundworm), Ancylostoma Duodenale (Hookworm), and Trichuris Trichiura (Whipworm)
Clinical Features
Strongyloides Stercoralis
Clinical Features
Anisakis Simplex (Anisakiasis) and Related Species
Clinical Features
Trematodes
Clinical Features
Acknowledgement
Suggested Readings
10. Non-neoplastic Disorders of the Colon
Abstract
Idiopathic Inflammatory Bowel Disease
Ulcerative Colitis
Clinical Features
Dysplasia In Ulcerative Colitis
Crohn’s Disease
Clinical Features
Ileal Pouch Enteritis (Pouchitis)
Collagenous Colitis
Clinical Features
Lymphocytic Colitis
Ischemic Colitis
Radiation Colitis
Diversion Colitis
Diverticular Disease–Associated Colitis
Mucosal Prolapse Or Solitary Rectal Ulcer Syndrome
Eosinophilic Proctocolitis
Systemic Mastocytosis
Mycophenolate Mofetil Colitis
Immune Checkpoint Receptor Inhibitor–Associated Colitis
Cord Colitis Syndrome
Nonsteroidal Antiinflammatory Drug Colitis
Chemotherapy Effect or Mucositis
Selected Readings
11. Gastrointestinal Polyposis Syndromes
Abstract
Adenomatous Polyposis Syndromes
Serrated Polyposis Syndrome
Peutz-Jeghers Syndrome
Juvenile Polyposis Syndrome
Cowden’s Syndrome
Cronkhite-Canada Syndrome
Hereditary Mixed Polyposis Syndrome
Miscellaneous Syndromes With Associated Gastrointestinal Polyposis
Suggested Readings
12. Epithelial Neoplasms of the Colorectum
Colorectal Polyps
Adenomatous Polyps
Neuroendocrine Proliferation In Adenomatous Polyps
Intramucosal Adenocarcinoma And “Carcinoma In Situ”
Molecular Features Of Adenomatous Polyps
Malignant Polyps
Invasive Adenocarcinoma Versus Misplaced Epithelium (Pseudoinvasion)
Serrated Polyps
Hyperplastic Polyps
Sessile Serrated Polyp/Adenoma
Traditional Serrated Adenomas
Molecular Alterations
Serrated Polyposis Syndrome
Colorectal Adenocarcinoma
Molecular Pathways For Colorectal Carcinogenesis
Lynch Syndrome
Uncommon Variants Of Colorectal Carcinomas
Morphologic Features Associated With Microsatellite Instability
Neuroendocrine Neoplasms
Suggested Readings
13. Molecular Testing of Gastrointestinal Neoplasms
Assessment Of Mismatch Repair Function
HER-2 in colorectal carcinoma
HER2 Testing in Upper Gastrointestinal Tract (Esophageal, Gastric, and Gastroesophageal Junction) Adenocarcinoma
Suggested Readings
14. Pathology of the Anal Canal
Abstract
Anal Anatomic and Histologic Landmarks
Inflammatory And Non-Neoplastic
Crohn’s Disease
Clinical Features
Hemorrhoids And Anal Tags
Clinical Features
Anal Tags
Anal And Perianal Squamous Neoplasia Terminology
Tumors And Precursor Lesions Of The Anal Canal
Anal Canal Squamous Intraepithelial Lesion
Ancillary Studies
Squamous Cell Carcinoma
Ancillary Studies
Molecular Pathology
Adenocarcinoma
Clinical Features
Ancillary Studies
Melanoma
Ancillary Studies
Molecular Pathology
Tumors And Precursor Lesions Of The Perianal Skin
Clinical Features
Condyloma Acuminatum
Clinical Features
Molecular Pathology
Perianal High-Grade Squamous Intraepithelial Lesion (Bowen’s Disease)
Clinical Features
Bowenoid Papulosis
Squamous Cell Carcinoma Of The Perianal Skin
Verrucous Carcinoma
Clinical Features
Molecular Pathology
Paget’s Disease
Clinical Features
Ancillary Studies
Immunohistochemistry
Suggested Readings
15. Pathology of the Gallbladder and Extrahepatic Bile Ducts
Abstract
Gallbladder
Dysplasia And Early Gallbladder Carcinoma
Advanced Gallbladder Carcinoma
Extrahepatic Bile Ducts
Carcinoma Of Extrahepatic Bile Ducts
Other Lesions Of The Gallbladder And Extrahepatic Bile Ducts
Suggested Readings
16. Non-Neoplastic and Neoplastic Pathology of the Pancreas
Abstract
Non-Neoplastic Diseases
Pancreatitis
Neoplastic Diseases
Neuroendocrine Tumors
Tumors With Acinar Differentiation
Frozen Section Evaluation and Diagnosis
Suggested Readings
17. Non-Neoplastic Disorders of the Liver
Major Histologic Patterns of Injury
Acute Hepatitis Pattern of Injury
Acute Viral (Hepatotropic) Hepatitis
Clinical Features
Nonhepatotropic Viral Infections
Clinical Features
Chronic Hepatitis Pattern of Injury
Chronic Viral Hepatitis
Autoimmune Hepatitis
Fatty Liver Disease or Steatohepatitis Pattern of Injury
Nonalcoholic Fatty Liver Disease
Alcoholic Liver Disease
Disorders of the Bile Ducts
Large Duct Obstruction
Primary Biliary Cholangitis
Primary Sclerosing Cholangitis
Laboratory Findings
Overlap Syndromes (Autoimmune Hepatitis, Primary Biliary Cholangitis, And Primary Sclerosing Cholangitis)
Vascular Pattern Of Injury
Budd-Chiari Syndrome
Clinical Features
Congestive (Cardiac) Hepatopathy
Clinical Features
Sinusoidal Obstruction Syndrome
Clinical Features
Portal Vein Thrombosis or Obstruction
Nodular Regenerative Hyperplasia
Clinical Features
Hepatoportal Sclerosis
Clinical Features
Peliosis Hepatis
Clinical Features
Drug-Induced Liver Injury
Clinical Features
Miscellaneous Patterns of Injury
“Almost Normal” Biopsy or Nonspecific Findings
Hepatic Granulomas
Necrosis
Metabolic Diseases
Iron Overload
Hereditary Hemochromatosis
Clinical Features
Secondary Iron Overload
Copper Accumulation Disorder
Clinical Features
Clinical Features
Glycogen Storage Diseases
Clinical Features
Clinical Features
Glycogenic Hepatopathy
Porphyrias
Suggested Readings
18. Liver Neoplasms
Epithelial Tumors Hepatocellular Tumors Focal Nodular Hyperplasia
Clinical Features
Hepatic Adenoma
Macroregenerative and Dysplastic Nodules
Hepatocellular Carcinoma
Fibrolamellar Carcinoma
Hepatoblastoma
Biliary TumorsBile Duct Hamartoma
Bile Duct Adenoma
Solitary Biliary Cyst
Polycystic Liver Disease
Mucinous Cystic Neoplasm
Cholangiocarcinoma
Combined Hepatocellular–Cholangiocarcinoma
Mesenchymal Tumors Benign Hemangioma
Infantile Hemangioma
Mesenchymal Hamartoma
Angiomyolipoma
Malignant Angiosarcoma
Epithelioid Hemangioendothelioma
Embryonal Sarcoma of the Liver
Primary Hepatic Lymphoma
Metastases
Suggested Readings
19. Gastrointestinal Lymphoma
Extranodal Marginal Zone B-cell Lymphoma of Mucosa Associated Lymphoid Tissue (MALT LYMPHOMA)
Immunoproliferative Small Intestinal Disease (a Heavy Chain Disease)
Follicular Lymphoma (Including Primary Duodenal-Type Follicular Lymphoma)
■ Mantle Cell Lymphoma
Large Cell and Aggressive B-Cell Lymphomas
■Diffuse Large B-Cell Lymphoma
■High-Grade B-Cell Lymphoma
Epstein-Barr Virus–Positive Diffuse Large B-cell Lymphoma, Not Otherwise Specified
Plasmablastic Lymphoma
■Burkitt Lymphoma
Epstein-Barr Virus–Positive Mucocutaneous Ulcer
Mature T- and Natural Killer Cell Neoplasms
Enteropathy-Associated T-Cell Lymphoma
Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma
Hepatosplenic T-Cell Lymphoma
Indolent T- and Natural Killer Cell Lymphoproliferative Disorders
Summary
Suggested Readings
20. Pathology of Liver, Small Bowel, and Pancreas Transplantation
Liver Transplantation
Pretransplant Donor Evaluation
Preservation or Ischemia-Reperfusion Injury
Laboratory Findings
Antibody-Mediated Rejection
Ancillary Studies
(Acute) T Cell–Mediated Rejection
Chronic (Ductopenic) Rejection
Complications of Transplantation
Portal Hyperperfusion Injury or Small-for-Size Graft Syndrome
Hepatic Venous Outflow Obstruction or Congestive Hepatopathy
Biliary Complications
Recurrent Disease
Small Bowel Transplantation
Acute Cellular Rejection
Antibody-Mediated Rejection
Chronic Rejection
Pancreas Transplantation
Evaluating Posttransplant Needle Core Biopsies
Cell-Mediated Rejection
Chronic Rejection and Graft Fibrosis
Chronic Graft Fibrosis
Other Complications
Recurrence of Primary Disease
Suggested Readings
Index
Confidence is ClinicalKey

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