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Genetic Polymorphism and Disease 1st Edition

ISBN: 9781032153162
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Διαστάσεις 28 × 20 cm
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Περιγραφή

Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. Some of these polymorphisms are linked to increased susceptibility to various diseases especially cancers, cardiovascular diseases, immune disorders, neurological pathologies. This book collates the reviews on the roles played by polymorphisms in critical metabolic, signal transduction, cell cycle or DNA repair genes either directly or indirectly in the disease mechanisms. The focus is on various techniques for identifying the various Single Nucleotide Polymorphisms (SNPs). Polymorphism studies document the affect SNPs, and their expressions have upon the functionality of the enzymes, proteins.

Key Features

  • Describes the genetic polymorphism and its various types
  • Discusses the role of genetic polymorphisms in modulating the risk of various human diseases
  • Explores various molecular techniques used for detecting GPs
  • Characterizes the role of SNPs in modulating the susceptibility of human diseases
  • Provides a genetic basis for individual variations in response to therapeutics

Περιεχόμενα

Chapter 1 – Genetic Polymorphisms – Classification, Structure, Detection and Function

Mujeeb Zafar Banday

Aga Syed Sameer

Saniya Nissar

 

Chapter 2 – Clinical relevance of Pharmacogenomics a road to personalized medicine

Nusrath Yasmeen

Shobana John

Vikram Kumar

Moudi M Alasmari

 

Chapter 3 – Diabetes and Role of SNPs in diabetes susceptibility

Johra Khan

Sayequa Dandoti

 

Chapter 4 – Genetic polymorphism associated with innate immune response to Malaria

Amre Nasr

Amir Abushouk

 

Chapter 5 – Xenobiotic Metabolic Enzyme Polymorphisms and cancer susceptibility

Saniya Nissar
Aga Syed Sameer
Mujeeb Zafar Banday
Fouzia Rashid

 

Chapter 6 – Genetic Polymorphisms in Matrix Metallo-Proteinase (MMP) Genes and Cancer

Mujeeb Zafar Banday

Saniya Nissar

Aga Syed Sameer

Ehtishamul Haq

Sabhiya Majid

 

Chapter 7 – Vitamin D receptor polymorphisms and diseases

Aga Syed Sameer

Mujeeb Zafar Banday

Saniya Nissar

Mansour AlQurashi

Abdullah Awadh

Alqassem Hakami

Israa A Malli

 

Chapter 8 – Genetic Polymorphism in Fatty Acid Metabolism Genes and Cancer Susceptibility

Mosin S Khan

Sunia Faiz

Iqra Farooq

Suhail S Lone

Sabhiya Majid

Waseem Qureshi

 

Chapter 9 – Single nucleotide polymorphisms (SNPs) and Parkinson’s disease

Saniya Nissar

Aga Syed Sameer

Mujeeb Zafar Banday

Sabhiya Majid

 

Chapter 10 – Genetic Polymorphisms, role in drug metabolism and effect on Clinical Pharmacy

Muneeb U Rehman

Shagufta Sheikh

Sanjeev Rana

Hilal A Wani

Aarif Ali

Qazi Danish

Sabhiya Majid

Nisar A Naikoo

Nouroz Sehar

Amjad Faihan Binlebdah

Azher Arafah

 

Chapter 11 – Role of genetic polymorphisms om Chronic Inflammatory disease

Saniya Nissar

Aga Syed Sameer

Mujeeb Zafar Banday

Roohi Rasool

 

Chapter 12 – Single nucleotide polymorphism related computational-resources part I: Databases

Nadiem Nazir Bhat

Showkat Ahmad Dar

Manmeet Kaur

Pallawi Kumari

 

Chapter 13 – Single nucleotide polymorphism related computational-resources part II: Algorithms

Nadiem Nazir Bhat

Showkat Ahmad Dar

Manmeet Kaur

Pallawi Kumari

 

Chapter 14 – Role of single nucleotide polymorphisms (SNPs) in common migraine

Aga Syed Sameer
Saniya Nissar
Mujeeb Zafar Banday
Kulsum Akhtar
Razaz Felemban
Moudi M Alasmari
Faheem Hyder Potto
Sheikh A Saeed

 

Chapter 15 – The Role of Vitamin D Single Nuclear Polymorphisms in Cancer Susceptibility

Abdullah A. Awadh

 

Chapter 16 – Genetic polymorphisms in fatty acid metabolism genes and cancer susceptibility

Racha Kerek

 

Chapter 17 – Toll-Like Receptor (TLR) Polymorphisms in Prostate Cancer

Payam BEHZADI

 

Chapter 18 – Role of Single Nucleotide Polymorphism of Cytochrome P450 Genes in Cancer Susceptibility

Faheem Hyder Pottoo

Sachin Kuma

Rajiv Kumar Tonk

 

Chapter 19 – Role of Single Nucleotide Polymorphisms of Inflammatory molecules in susceptibility to Cardiovascular diseases (CVDs)

Saniya Nissar

Vishal Kumar Deb

Ahmad Rabbani

Sabhiya Majid

Amir Abushouk

Johra Khan

Bader H Khawaji

Ruqaya Aziz

Mujeeb Zafar Banday

Yasmeen Nusrath

 

Chapter 20 – Role of Single Nucleotide Polymorphisms of Inflammatory molecules in susceptibility to Cardiovascular diseases (CVDs)

Syed Mudassar

Kulsum Akhtar

Ishrat Parveiz Bhat

 

Chapter 21 – Cytokine polymorphism and their role in modulating cancer risk

Mosin S Khan

Iqra Farooq

Sunia Faiz

Suhail S Lone

Sabhiya Majid

Waseem Qureshi

 

Chapter 22 – Gastric Cancer and genetic polymorphism in modulating the susceptibility

Muneeb U Rehman

Shagufta Sheikh

Sanjeev Rana

Hilal A Wani

Aarif Ali

Nouroz Sehar

Sabhiya Majid

Nisar A Naikoo

Bashayr M. Alsuwayni

Azher Arafah

 

Chapter 23 – Cytokine Gene Polymorphisms & their Role in Autoimmune Diseases

Syed Mudassar

Kulsum Akhtar

Ishrat Parveiz Bhat

Aga Syed Sameer

Syed Douhath Yousuf

 

Chapter 24 – Genomic disturbances associated with penile cancer and novel therapies

Herney Andrés García-Perdomo

María Juliana Chaves-Medina

 

Chapter 25 – Role of Genetic Polymorphisms in Gastric Cancer Susceptibility

Syed Mudassar

Syed Douhath Yousuf