Volume One
Part 1 History, Definitions, and Prevalence
Chapter 1 From Hippocrates to the Obesity Society: A Brief History
George A. Bray and Marta Sumińska
Chapter 2 Obesity in Art and Literature
Fiona Haslam and David Haslam
Chapter 3 Measurement of Total Adiposity, Regional Fat Depots, and Ectopic Fat
Steven B. Heymsfield, Brooke Smith, and Matthew D. Robson
Chapter 4 Anthropometric Indicators of Adiposity in Relation to the Gold Standards
Peter T. Katzmarzyk
Chapter 5 Worldwide and Regional Prevalence of Obesity
Jacob C. Seidell
Chapter 6 Age, Sex, Ethnicity, and Other Sources of Variation in the Prevalence of Obesity
Sohyun Park and Heidi M. Blanck
Part 2 Biological Determinants of Obesity
Chapter 7 Bioenergetics and Obesity
Matthew D. Lynes and Yu-Hua Tseng
Chapter 8 Mitochondrial Metabolic Inefficiencies in Skeletal Muscle: Implications for Obesity and Weight Loss
Mary-Ellen Harper, Ruth McPherson, and Robert Dent
Chapter 9 Human Experimental Overfeeding
George A. Bray and Claude Bouchard
Chapter 10 Biology of Calorie Restriction and Intermittent Fasting
Leonie Heilbronn, Kai Liu, and Luigi Fontana
Chapter 11 Genetic Epidemiology and Obesity
Karri Silventoinen
Chapter 12 Genetic Variation and Obesity
Ruth J. F. Loos
Chapter 13 Single Gene Defects and Obesity
Héléna Mosbah, Christine Poitou, and Karine Clément
Chapter 14 Micro and Long RNAs as Regulators in Obesity
Jean-Francois Landrier, Flavie Sicard, and Lourdes Mounien
Chapter 15 Epigenetics and Obesity
Charlotte Ling and Sonia Garcia-Calzon
Chapter 16 The Role of Adipocyte Precursors in Development and Obesity
Tammy Ying and Rebecca A. Simmons
Chapter 17 Small Animal Models of Obesity
Heike Münzberg, Christopher D. Morrison, and J. Michael Salbaum
Chapter 18 Obesity in Nonhuman Primates
Barbara C. Hansen, Daniel Harrison, Vernon Volante, Nana Gletsu-Miller, and Kai-Lin Catherine Jen
Chapter 19 The Transcriptome, Proteome, and Metabolome of Obesity
Monalisa Hota, Lijin Wang, Pratap Seshachalam, and Sujoy Ghosh
Chapter 20 CNS Regulation of Energy Balance
Justin L. Grobe and Matthew J. Potthoff
Chapter 21 Gastrointestinal Regulation of Energy Balance
Timothy S. Kairupan, Nova H. Kapantow, and Akio Inui
Chapter 22 Gut Microbiome and Obesity
Kristina Martinez-Guryn and Eugene B. Chang
Chapter 23 Sympathetic Nervous System and Obesity
Elisabeth Lambert
Chapter 24 Hypothalamic-Pituitary Hormones and Obesity
Jonathan Q. Purnell, Mary Samuels, and Maria Fleseriu
Chapter 25 Brown, Beige, and White Adipocyte Development
Shingo Kajimura
Chapter 26 Adipose Tissue Metabolism, Adipokines, and Obesity
Ricardo J. Samms and Philipp E. Scherer
Chapter 27 Hepatic, Visceral, Pancreatic, and Cardiac Fat Deposition
Amalia Gastaldelli
Chapter 28 Skeletal Muscle Metabolism and Obesity
Polina M. Krassovskaia, Nicholas T. Broskey, and Joseph A. Houmard
Chapter 29 Resting Metabolic Rate, Thermic Effect of Food, and Obesity
Yves Schutz and Abdul Dulloo
Chapter 30 Energy Cost of Exercise, Postexercise Metabolic Rates, and Obesity
Robert Ross, Erin Miller, Emily John, and Laura Guzmán Caballero
Chapter 31 Energy Partitioning, Substrate Oxidation Rates, and Obesity
Angelo Tremblay, Margriet Westerterp-Plantenga, and Patrick Schrauwen
Chapter 32 COVID-19, Other Microbial Infections, and Obesity
Md Akheruzzaman, Vijay Hegde, and Nikhil V. Dhurandhar
Part 3 Behavioral Determinants of Obesity
Chapter 33 Obesity and Dietary Intake
Eunjin Cheon, Lissa A. Davis, Vinicius M. Valicente, Yu Wang, and Richard D. Mattes
Chapter 34 Beverages and Obesity: A Review of Current Scientific Evidence
Miaobing Zheng, Sofus C. Larsen, Nanna J. Olsen, and Berit L. Heitmann
Chapter 35 Obesity and Sedentary Time at Work and Home
Stuart J.H. Biddle and Gregory J.H. Biddle
Chapter 36 Leisure Time Physical Activity and Obesity
Julianne G. Clina, Drew Sayer, and James O. Hill
Chapter 37 Role of Early Life Nutrition & Breastfeeding on Obesity Development
Maryam Kebbe, Kelsey Goynes, and Leanne M. Redman
Chapter 38 Tobacco Use, Marijuana Use, Vaping, and Obesity
Bernard F. Fuemmeler, Kristina L. Tatum, and D. Jeremy Barsell
Chapter 39 Sleep and Obesity
Silvia Cerolini and Caterina Lombardo
Chapter 40 Eating Disorders and Obesity
Jon M. Mond and Timothy Gill
Part 4 Environmental, Social, and Cultural Determinants of Obesity
Chapter 41 The Role of the Food Industry in Obesity
Martin Binks
Chapter 42 Transportation Policies and Obesity
James E. Peterman and David R. Bassett, Jr.
Chapter 43 Urban Environment and Obesity
Katherine R. White and Lawrence D. Frank
Chapter 44 Social and Economic Factors Related to Obesity Across the Globe
Penny Gordon-Larsen and Pasquale E. Rummo
Chapter 45 Influence of Culture on Obesity
Alison Tovar, Peter T. Katzmarzyk, and Aviva Must
Chapter 46 Environmental Chemicals and Obesity
Sumira Phatak, Amanda S. Janesick, Thaddeus T. Schug, Jerrold J. Heindel and Bruce Blumberg
Part 5 Consequences of Obesity
Chapter 47 Obesity and Mortality
Thorkild I.A. Sørensen, Justin C. Brown, and Terese Sara Høj Jørgensen
Chapter 48 Obesity and Heart Disease
Alexandra M. Sanchez, Nadia I. Abelhad, Andrew Elagizi, Sergey Kachur, Hector O. Ventura, and Carl J. Lavie
Chapter 49 Obesity and Hypertension
John E. Hall, Ana C. M. Omoto, Jussara M. do Carmo, Alexandre A. da Silva, Zhen Wang, Alan Mouton, Xuan Li, and Michael E. Hall
Chapter 50 Obesity and Lipoprotein Metabolism
Sally Chiu and Ronald M. Krauss
Chapter 51 Obesity and Insulin Resistance
John P. Kirwan and Christopher L. Axelrod
Chapter 52 Obesity and Type 2 Diabetes
Norbert Stefan
Chapter 53 Obesity and Metabolic Syndrome
André Tchernof and Jean-Pierre Després
Chapter 54 Obesity and Cancer
Alpa V. Patel and Lauren R. Teras
Chapter 55 Obesity and Inflammation
Sierra Nance, Ramiah Jacks, and Carey Lumeng
Chapter 56 Obesity, Gallbladder, and Gastrointestinal Diseases
Michael Camilleri and Andres Acosta
Chapter 57 Obesity and Liver Diseases
Münevver Demir, Josephine Frohme, and Frank Tacke
Chapter 58 Obesity, Lung Function, and Lung Disease
Anne E. Dixon and Swati A. Bhatawadekar
Chapter 59 Obesity and Gout
Lorraine Watson and Edward Roddy
Chapter 60 Obesity, Osteoarthritis, and Bone Disorders
Sanjay Mediwala and Dennis T. Villareal
Chapter 61 Obesity and Cognitive Decline
Adam Tabak, Vince Fazekas-Pongor, Stefano Tarantini, Priya Balasubramanian, Anna Csiszar and Zoltan Ungvari
Chapter 62 Obesity, Mental Health, and Health-related Quality of Life
Osnat C. Melamed, Peter Selby, and Valerie H. Taylor
Chapter 63 Obesity and Reproductive Dysfunction
Ronald Swerdloff, Waleed Butt, and Christina Wang
Chapter 64 Obesity in Pregnancy Complications and Outcomes
Amy M. Valent and Aaron B. Caughey
Chapter 65 Obesity, Growth, Development, Metabolic Disorder, and Insulin Resistance in Pediatrics
Nicola Santoro, Alfonso Galderisi, and Sonia Caprio
Chapter 66 Bias, Discrimination, and Obesity
Rebecca M. Puhl
Volume Two
Part 1 Prevention and Economic Outcomes of Obesity
Chapter 1 Dietary Changes in Human Evolution: Implications for the Prevention of Obesity
Peter Andrews and Richard Johnson
Chapter 2 Evolutionary Changes in Physical Activity, Diet, and Energy Expenditure: Implications for the Prevention of Obesity
Herman Pontzer
Chapter 3 Prevention of Obesity in Adults
Suzanne Phelan
Chapter 4 The Prevention of Obesity in Children and Adolescents
Tim Lobstein and Louise Baur
Chapter 5 Re-engineering the Built Environment: Progress in Schools, Worksites, Neighborhoods, and Communities
Stephanie T. Broyles and Maura M. Kepper
Chapter 6 The Economic Costs of Obesity
Adam Biener, John Cawley, and Chad Meyerhoefer
Chapter 7 Cost-effectiveness of Obesity Prevention and Treatment
Jaithri Ananthapavan, Marj Moodie, and Victoria Brown
Chapter 8 Role of Government and Non-Government Organizations in the Obesity Pandemic and Its Prevention
Simon Barquera, Mariel White, Gabriela Argumedo, Carolina Batis, and Juan Rivera-Dommarco
Chapter 9 Role of Reimbursement in the Delivery of Treatment for Obesity in Adults and Children
Chika Vera Anekwe, Veronica R. Johnson, Matthew J. Townsend, and Fatima Cody Stanford
Part 2 Evaluation of the Patients with Overweight or Obesity
Chapter 10 Classification, Evaluation, and Staging of the Patient with Obesity
Robert F. Kushner and Amanda Velazquez
Chapter 11 Indicators of Central Adiposity: A Critical Evaluation of Their Usefulness
Ian J. Neeland, Jean-Pierre Després, André C. Carpentier, and Paul Poirier
Chapter 12 Genetic Obesity Syndromes
I. Sadaf Farooqi and Stephen O’Rahilly
Chapter 13 Ethnic and Racial Considerations in the Evaluation of the Patient with Obesity
Peter T. Katzmarzyk, Sean Wharton, Fatima Cody Stanford, and Daniel G. Aaron
Part 3 Lifestyle in the Management of Obesity: Behavioral Modification, Diet, and Exercise
Chapter 14 Best Practices: Obesity and the Primary Care Providers
Christine Gallagher, Donna H. Ryan, and William Dietz
Chapter 15 In-person Behavioral Approaches for Weight Management
Jena S. Tronieri and Thomas A. Wadden
Chapter 16 Behavioral Interventions Delivered Remotely
Christoph Höchsmann and Corby K. Martin
Chapter 17 Cultural Considerations in Behavioral Therapy for Management of Obesity
Robert L. Newton, Jr., Elva Arredondo, Patricia Dionicio, and Noe C. Crespo
Chapter 18 Diet Composition and Weight Loss: Is a Calorie a Calorie?
Kevin D. Hall
Chapter 19 Circadian Rhythms and Weight Loss: Timed Food Intake
Emily N. C. Manoogian, Nikko R. Gutierrez, Erika Padilla, and Michael J. Wilkinson
Chapter 20 Comparison of Modern-Millennial Diets
Monica Dinu, Daniela Martini, Francesco Sofi, Mauro Serafini, Marisa Porrini, and Donato Angelino
Chapter 21 Dietary Energy Density and Its Contribution to Weight Control
Faris M. Zuraikat and Barbara J. Rolls
Chapter 22 Dietary Patterns as a Basis for Diet Selection
Catherine Champagne
Chapter 23 Physical Activity and Weight Loss: Volume, Intensity, and Mode
John M. Jakicic and Renee J. Rogers
Chapter 24 Modifying Sedentary Behavior for the Prevention and Treatment of Obesity
Bethany Barone Gibbs
Chapter 25 Preventing Weight Regain After Weight Loss
Stephen D. Anton and Michael G. Perri
Chapter 26 Personalized and Precision Nutrition in the Management of Obesity: Can We Tailor the Treatment to the Patient?
George Thom and Mike Lean
Part 4 Medications in the Management of Obesity
Chapter 27 Drug-associated Weight Gain and Clinical Alternatives
Barbara Ameer and Michael A. Weintraub
Chapter 28 Mechanisms of Drug Action in Obesity
M. Furkan Burak, Nawfal W. Istfan, and Caroline M. Apovian
Chapter 29 Metabolic Effects of Progressive Weight Loss
Faidon Magkos
Chapter 30 Older Drugs Used to Manage Obesity: Sympathomimetics and Orlistat
Frank L. Greenway and George A. Bray
Chapter 31 Serotonergic Drugs for Treating Obesity
Mireille J. Serlie
Chapter 32 Antidiabetic Drugs that Reduce Weight and Are Cardioprotective
Carolina M. Perdomo, Javier Escalada, and Gema Frühbeck
Chapter 33 Approved Combination Agents: Phentermine/Topiramate
W. Timothy Garvey
Chapter 34 Approved Combination Agents: Naltrexone-Bupropion
Igho J. Onakpoya and Carl J. Heneghan
Chapter 35 Drugs That Affect Body Weight: The Glucagon-like Peptide-1 Agonists
Randa Ghazal-Asswad and John P.H. Wilding
Chapter 36 Hydrogels in the Treatment of Obesity
Frank L. Greenway
Chapter 37 Dual and Triple-Action Peptides
Thinzar Min and Stephen C. Bain
Chapter 38 Antiobesity Medications on the Horizon
Sarah R. Barenbaum and Louis J. Aronne
Chapter 39 Treatments for Rare Forms of Genetic Obesity
Joan C. Han, Nandini Basuray, and Andrea M. Haqq
Chapter 40 Special Issues in Using Medications in Children & Adolescents
Jaime M. Moore, Stephen R. Daniels, and Claudia K. Fox
Chapter 41 Dietary Supplements and Weight Management
Carol J. Haggans, Rebecca B. Costello, Leila G. Saldanha, Abby G. Ershow, and William T. Cefalu
Part 5 Surgical Interventions for Obesity
Chapter 42 Historical Overview of Metabolic and Bariatric Surgery
Henry Buchwald
Chapter 43 Overview: Current Metabolic Operations and Long-term Outcomes
Robert C. Ross, Vance L. Albaugh, Ali Aminian, and Philip R. Schauer
Chapter 44 Effects of Metabolic Surgery on Type 2 Diabetes
Pia Roser, Ghassan Chamseddine, and Francesco Rubino
Chapter 45 Cardiovascular Outcomes in Metabolic Surgery
Wen Hui Tan, Tammy Kindel, Steven Nissen, and Philip R. Schauer
Chapter 46 Effect of Bariatric Surgery on Cancer
Justin C. Brown, Andrea M. Stroud, Priya A. Rajdev, and Bruce M. Wolfe
Chapter 47 Bariatric Surgery in Pediatric Patients
Sarah Ogle and Thomas Inge
Chapter 48 Other Bariatric Procedures: Nerve Stimulation, Gastric Balloons, Intestinal Liners, and Others
Cullen F. Roberts, Colston Edgerton, and Scott A. Shikora
