Part 1 History, Definitions, and Prevalence
Chapter 1 From Hippocrates to the Obesity Society: A Brief History
George A. Bray and Marta Sumińska
Chapter 2 Obesity in Art and Literature
Fiona Haslam and David Haslam
Chapter 3 Measurement of Total Adiposity, Regional Fat Depots, and Ectopic Fat
Steven B. Heymsfield, Brooke Smith, and Matthew D. Robson
Chapter 4 Anthropometric Indicators of Adiposity in Relation to the Gold Standards
Peter T. Katzmarzyk
Chapter 5 Worldwide and Regional Prevalence of Obesity
Jacob C. Seidell
Chapter 6 Age, Sex, Ethnicity, and Other Sources of Variation in the Prevalence of Obesity
Sohyun Park and Heidi M. Blanck
Part 2 Biological Determinants of Obesity
Chapter 7 Bioenergetics and Obesity
Matthew D. Lynes and Yu-Hua Tseng
Chapter 8 Mitochondrial Metabolic Inefficiencies in Skeletal Muscle: Implications for Obesity and Weight Loss
Mary-Ellen Harper, Ruth McPherson, and Robert Dent
Chapter 9 Human Experimental Overfeeding
George A. Bray and Claude Bouchard
Chapter 10 Biology of Calorie Restriction and Intermittent Fasting
Leonie Heilbronn, Kai Liu, and Luigi Fontana
Chapter 11 Genetic Epidemiology and Obesity
Karri Silventoinen
Chapter 12 Genetic Variation and Obesity
Ruth J. F. Loos
Chapter 13 Single Gene Defects and Obesity
Héléna Mosbah, Christine Poitou, and Karine Clément
Chapter 14 Micro and Long RNAs as Regulators in Obesity
Jean-Francois Landrier, Flavie Sicard, and Lourdes Mounien
Chapter 15 Epigenetics and Obesity
Charlotte Ling and Sonia Garcia-Calzon
Chapter 16 The Role of Adipocyte Precursors in Development and Obesity
Tammy Ying and Rebecca A. Simmons
Chapter 17 Small Animal Models of Obesity
Heike Münzberg, Christopher D. Morrison, and J. Michael Salbaum
Chapter 18 Obesity in Nonhuman Primates
Barbara C. Hansen, Daniel Harrison, Vernon Volante, Nana Gletsu-Miller, and Kai-Lin Catherine Jen
Chapter 19 The Transcriptome, Proteome, and Metabolome of Obesity
Monalisa Hota, Lijin Wang, Pratap Seshachalam, and Sujoy Ghosh
Chapter 20 CNS Regulation of Energy Balance
Justin L. Grobe and Matthew J. Potthoff
Chapter 21 Gastrointestinal Regulation of Energy Balance
Timothy S. Kairupan, Nova H. Kapantow, and Akio Inui
Chapter 22 Gut Microbiome and Obesity
Kristina Martinez-Guryn and Eugene B. Chang
Chapter 23 Sympathetic Nervous System and Obesity
Elisabeth Lambert
Chapter 24 Hypothalamic-Pituitary Hormones and Obesity
Jonathan Q. Purnell, Mary Samuels, and Maria Fleseriu
Chapter 25 Brown, Beige, and White Adipocyte Development
Shingo Kajimura
Chapter 26 Adipose Tissue Metabolism, Adipokines, and Obesity
Ricardo J. Samms and Philipp E. Scherer
Chapter 27 Hepatic, Visceral, Pancreatic, and Cardiac Fat Deposition
Amalia Gastaldelli
Chapter 28 Skeletal Muscle Metabolism and Obesity
Polina M. Krassovskaia, Nicholas T. Broskey, and Joseph A. Houmard
Chapter 29 Resting Metabolic Rate, Thermic Effect of Food, and Obesity
Yves Schutz and Abdul Dulloo
Chapter 30 Energy Cost of Exercise, Postexercise Metabolic Rates, and Obesity
Robert Ross, Erin Miller, Emily John, and Laura Guzmán Caballero
Chapter 31 Energy Partitioning, Substrate Oxidation Rates, and Obesity
Angelo Tremblay, Margriet Westerterp-Plantenga, and Patrick Schrauwen
Chapter 32 COVID-19, Other Microbial Infections, and Obesity
Md Akheruzzaman, Vijay Hegde, and Nikhil V. Dhurandhar
Part 3 Behavioral Determinants of Obesity
Chapter 33 Obesity and Dietary Intake
Eunjin Cheon, Lissa A. Davis, Vinicius M. Valicente, Yu Wang, and Richard D. Mattes
Chapter 34 Beverages and Obesity: A Review of Current Scientific Evidence
Miaobing Zheng, Sofus C. Larsen, Nanna J. Olsen, and Berit L. Heitmann
Chapter 35 Obesity and Sedentary Time at Work and Home
Stuart J.H. Biddle and Gregory J.H. Biddle
Chapter 36 Leisure Time Physical Activity and Obesity
Julianne G. Clina, Drew Sayer, and James O. Hill
Chapter 37 Role of Early Life Nutrition & Breastfeeding on Obesity Development
Maryam Kebbe, Kelsey Goynes, and Leanne M. Redman
Chapter 38 Tobacco Use, Marijuana Use, Vaping, and Obesity
Bernard F. Fuemmeler, Kristina L. Tatum, and D. Jeremy Barsell
Chapter 39 Sleep and Obesity
Silvia Cerolini and Caterina Lombardo
Chapter 40 Eating Disorders and Obesity
Jon M. Mond and Timothy Gill
Part 4 Environmental, Social, and Cultural Determinants of Obesity
Chapter 41 The Role of the Food Industry in Obesity
Martin Binks
Chapter 42 Transportation Policies and Obesity
James E. Peterman and David R. Bassett, Jr.
Chapter 43 Urban Environment and Obesity
Katherine R. White and Lawrence D. Frank
Chapter 44 Social and Economic Factors Related to Obesity Across the Globe
Penny Gordon-Larsen and Pasquale E. Rummo
Chapter 45 Influence of Culture on Obesity
Alison Tovar, Peter T. Katzmarzyk, and Aviva Must
Chapter 46 Environmental Chemicals and Obesity
Sumira Phatak, Amanda S. Janesick, Thaddeus T. Schug, Jerrold J. Heindel and Bruce Blumberg
Part 5 Consequences of Obesity
Chapter 47 Obesity and Mortality
Thorkild I.A. Sørensen, Justin C. Brown, and Terese Sara Høj Jørgensen
Chapter 48 Obesity and Heart Disease
Alexandra M. Sanchez, Nadia I. Abelhad, Andrew Elagizi, Sergey Kachur, Hector O. Ventura, and Carl J. Lavie
Chapter 49 Obesity and Hypertension
John E. Hall, Ana C. M. Omoto, Jussara M. do Carmo, Alexandre A. da Silva, Zhen Wang, Alan Mouton, Xuan Li, and Michael E. Hall
Chapter 50 Obesity and Lipoprotein Metabolism
Sally Chiu and Ronald M. Krauss
Chapter 51 Obesity and Insulin Resistance
John P. Kirwan and Christopher L. Axelrod
Chapter 52 Obesity and Type 2 Diabetes
Norbert Stefan
Chapter 53 Obesity and Metabolic Syndrome
André Tchernof and Jean-Pierre Després
Chapter 54 Obesity and Cancer
Alpa V. Patel and Lauren R. Teras
Chapter 55 Obesity and Inflammation
Sierra Nance, Ramiah Jacks, and Carey Lumeng
Chapter 56 Obesity, Gallbladder, and Gastrointestinal Diseases
Michael Camilleri and Andres Acosta
Chapter 57 Obesity and Liver Diseases
Münevver Demir, Josephine Frohme, and Frank Tacke
Chapter 58 Obesity, Lung Function, and Lung Disease
Anne E. Dixon and Swati A. Bhatawadekar
Chapter 59 Obesity and Gout
Lorraine Watson and Edward Roddy
Chapter 60 Obesity, Osteoarthritis, and Bone Disorders
Sanjay Mediwala and Dennis T. Villareal
Chapter 61 Obesity and Cognitive Decline
Adam Tabak, Vince Fazekas-Pongor, Stefano Tarantini, Priya Balasubramanian, Anna Csiszar and Zoltan Ungvari
Chapter 62 Obesity, Mental Health, and Health-related Quality of Life
Osnat C. Melamed, Peter Selby, and Valerie H. Taylor
Chapter 63 Obesity and Reproductive Dysfunction
Ronald Swerdloff, Waleed Butt, and Christina Wang
Chapter 64 Obesity in Pregnancy Complications and Outcomes
Amy M. Valent and Aaron B. Caughey
Chapter 65 Obesity, Growth, Development, Metabolic Disorder, and Insulin Resistance in Pediatrics
Nicola Santoro, Alfonso Galderisi, and Sonia Caprio
Chapter 66 Bias, Discrimination, and Obesity
Rebecca M. Puhl
