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Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 10th Edition 2-Volume Set

ISBN: 9780323934992
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Περιγραφή

Offering more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 10th Edition, remains your #1 choice for authoritative, comprehensive information in this challenging field. Meticulously updated by a new editorial team of Drs. Martin J. Blaser, Jeffrey I. Cohen, and Steven M. Holland, this two-volume masterwork brings together the knowledge and expertise of more than 650 contributing authors who are outstanding scholars and experts in their fields. For ID specialists and general practitioners alike, PPID provides a balanced, detailed perspective for any patient you encounter with a complex or difficult-to-treat infectious disease.
New to this edition
  • Updated throughout, eg: COVID-19 content, updates on Multisystem Inflammatory Syndrome in Children (MIS-C), XDR and complicated MDR tuberculosis, HIV prevention, transplant infections, measles elimination setbacks, the use of monoclonal antibodies to target antibiotic-resistant bacterial pathogens
  • Add more visuals: algorithms, text à table, short view summaries at start of chapters (not all chapters had these)
Key Features
  • Organizes content both by individual pathogens and by important clinical syndromes, broadening the context to clearly present relevant, complex clinical information.
  • Contains multiple new chapters on both SARS-CoV-2 and anti-fungal therapy, as well as new chapters on bacteriophages and related agents, infections following traumatic injuries, and communication to the public about infectious diseases
  • Provides up-to-date coverage of recent advances in the field: an increasing understanding of the agents, immune responses, and the growing armamentarium of diagnostics (such as polymerase chain reaction and next-generation sequencing); new treatments (such as monoclonal antibodies, new antifungals, antivirals, and phage therapy); and emerging preventive measures (such as new vaccines being developed for RSV)
  • Features more than 1,500 high-quality, full-color photographs―with many new to this edition
  • Shares the extensive experience of new editors Drs. Jeffrey I. Cohen and Steven M. Holland, both from the National Institutes of Health, as well as a new team of expert associate editors, Drs. Yohei Doi, Wendy S. Garrett, Ann R. Falsey, Eleanor Wilson, Kieren Marr, and Edward Mitre
  • Includes perspectives from hundreds of leading experts from a truly global community, including authors from Australia, Canada, and countries in Europe, Asia, and South America
  • Includes regular updates online for the life of the edition
  • An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date

Περιεχόμενα

PART I: BASIC PRINCIPLES IN THE DIAGNOSIS AND MANAGEMENT OF INFECTIOUS DISEASES
Section A: Microbial Pathogens

1. A Molecular Perspective of Microbial Pathogenicity

2. The Human Microbiome

3. Prebiotics, Probiotics, and Synbiotics

Section B: Host Defense Mechanisms

4. Innate (General or Nonspecific) Host Defense Mechanisms

5. Adaptive Immunity: Antibodies and Immunodefiencies

6. Cell-Mediated Defense Against Infection

7. Mucosal Immunity

8. Granulocytic Phagocytes

9. Complement and Deficiencies

10. Human Genetics and Infection

11. Nutrition, Immunity, and Infection

12. Evaluation of the Patient with Suspected Immunodeficiency

Section C: Epidemiology of Infectious Disease

13. Principles of Applied Epidemiology for the Practice of Infectious Diseases

14. Emerging and Reemerging Infectious Disease Threats

15. Bioterrorism: An Overview

Section D: Clinical Microbiology

16. The Clinician and the Microbiology Laboratory: Test Ordering, Specimen Collection, and Result Interpretation

Section E: Antiinfective Therapy

17. Principles of Anti-Infective Therapy

18. Molecular Mechanisms of Antibiotic Resistance in Bacteria

19. Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents

20. Penicillins and β-Lactamase Inhibitors

21. Cephalosporins and Cephalosporin/β-Lactamase Inhibitor Combinations

22. Carbapenems, Carbapenem/β-Lactamase Inhibitor Combinations, and Aztreonam

23. Antibiotic Allergy

24. Aminoglycosides

25. Tetracyclines, Tetracycline Derivatives, and Chloramphenicol

26. Rifamycins

27. Metronidazole

28. Macrolides and Clindamycin

29. Glycopeptides (Vancomycin and Teicoplanin) and Lipoglycopeptides (Telavancin, Oritavancin, and Dalbavancin)

30. Streptogramins (Quinupristin-Dalfopristin) and Lipopeptides (Daptomycin)

31. Polymyxins (Polymyxin B and Colistin)

32. Linezolid,Tedizolid, and Other Oxazolidinones

33. Sulfonamides and Trimethoprim; Trimethoprim-Sulfamethoxazole

34. Quinolones

35. Antibiotics in Advanced Development and Other Agents

36. Urinary Tract Agents: Nitrofurantoin, Fosfomycin and Methenamine

37. Topical Antibacterials

38. Antimycobacterial Agents

39. Bacteriophage Therapy, Endolysin Therapy and Antimicrobial Peptide Therapy

40. Antifungal Agents: Polyene Antifungals

41. Antifungal Drugs: Azole

42. Antifungal Drugs: Echinocandins and Other Beta-D-glucan Inhibitors

43. Antifungal Drugs: Flucytosine

44. Antimalarial Drugs

45. Drugs for Protozoal Infections Other Than Malaria

46. Drugs for Helminths

47. Antiviral Agents: General Principles

48. Antiviral Drugs for Influenza and Other Respiratory Virus Infections Except for SARS-CoV-2

49. Antivirals Against Herpesviruses

50. Antiviral Drugs Against Hepatitis Viruses

51. Miscellaneous Antivirals Agents (Interferons, Tecovirimat, Imiquimod, Pocapavir)

52. Immunomodulators

53. Hyperbaric Oxygen

54. Antimicrobial Stewardship

55. Designing and Interpreting Clinical Studies in Infectious Diseases

56. Outpatient Parenteral Antimicrobial Therapy

PART II: MAJOR CLINICAL SYNDROMES
Section A: Fever

57. Temperature Regulation and the Pathogenesis of Fever

58. Fever of Unknown Origin

59. The Acutely Ill Patient with Fever and Rash

Section B: Upper Respiratory Tract Infections

60. The Common Cold

61. Pharyngitis

62. Acute Laryngitis

63. Otitis Externa, Otitis Media, and Mastoiditis

64. Sinusitis

65. Epiglottitis

66. Infections of the Oral Cavity, Neck, and Head

Section C: Pleuropulmonary and Bronchial Infections

67. Acute Bronchitis

68. Acute Exacerbations of Chronic Obstructive Pulmonary Disease

69. Acute Pneumonia

70. Pleural Effusion and Empyema

71. Bacterial Lung Abscess

72. Chronic Pneumonia

73. Cystic Fibrosis

Section D: Urinary Tract Infections

74. Urinary Tract Infections

Section E: Sepsis

75. Sepsis and Septic Shock

Section F: Intraabdominal Infections

76. Peritonitis and Intraperitoneal Abscesses

77. Infections of the Liver and Biliary System (Liver Abscess, Cholangitis, Cholecystitis)

78. Pancreatic Infection

79. Splenic Abscess

80. Appendicitis

81. Diverticulitis and Neutropenic Enterocolitis

Section G: Cardiovascular Infections

82. Endocarditis and Intravascular Infections

83. Prosthetic Valve Endocarditis

84. Infections of Nonvalvular Cardiovascular Devices

85. Prophylaxis of Infective Endocarditis

86. Myocarditis and Pericarditis

87. Mediastinitis

Section H: Central Nervous System Infections

88. Approach to the Patient with Central Nervous System Infection

89. Acute Meningitis

90. Chronic Meningitis

91. Encephalitis

92. Brain Abscess

93. Subdural Empyema, Epidural Abscess, and Suppurative Intracranial Thrombophlebitis

94. Cerebrospinal Fluid Shunt and Drain Infections

Section I: Skin and Soft Tissue Infections

95. Cellulitis, Necrotizing Fasciitis, and Subcutaneous Tissue Infections

96. Myositis and Myonecrosis

97. Lymphadenitis and Lymphangitis

Section J: Gastrointestinal Infections and Food Poisoning

98. Syndromes of Enteric Infection

99. Esophagitis

100. Diarrhea with Little or No Fever

101. Acute Dysentery Syndromes (Diarrhea with Fever)

102. Typhoid Fever, Paratyphoid Fever, and Typhoidal Fevers

103. Foodborne Disease (Food Poisoning)

104. Tropical Sprue and Environmental Enteric Dysfunction

Section K: Bone and Joint Infections

105. Infectious Arthritis of Native Joints

106. Osteomyelitis

107. Orthopaedic Implant-Associated Infections

Section L: Diseases of The Reproductive Organs and Sexually Transmitted Diseases

108. Anogenital Skin and Mucous Membrane Lesions

109. Urethritis

110. Vulvovaginitis and Cervicitis

111. Infections of the Female Pelvis

112. Prostatitis, Epididymitis, and orchitis

Section M: Eye Infections

113. Introduction to Eye Infections

114. Microbial Conjunctivitis

115. Microbial Keratitis

116. Endophthalmitis

117. Infectious Causes of Uveitis

118. Periocular Infections

Section N: Hepatitis

119. Viral Hepatitis

Section O: Acquired Immunodeficiency Syndrome

120. Human Immunodeficiency Viruses

121. Global Perspectives on Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome

122. Epidemiology and Prevention of AIDS and HIV Infection, Including Preexposure Prophylaxis and HIV Vaccine Development

123. Diagnosis of Human Immunodeficiency Virus Infection

124. The Immunology of HIV-1 Infection, Mechanisms of Viral Persistence, and Prospects for Cure

125. General Clinical Manifestations of Human Immunodeficiency Virus Infection (Including Acute Retroviral Syndrome and Oral, Cutaneous, Renal, Ocular, Metabolic, and Cardiac Diseases)

126. Pulmonary Manifestations of Human Immunodeficiency Virus Infection

127. Gastrointestinal Hepatobiliary and Pancreatic Manifestations of Human Immunodeficiency Virus Infection

128. Neurologic Diseases Caused By Human Immunodeficiency Virus Type 1 and Opportunistic Infections

129. Pediatric Human Immunodeficiency Virus Infection

130. Antiretroviral Therapy for Human Immunodeficiency Virus Infection

131. Management of Opportunistic Infections Associated with Human Immunodeficiency Virus Infection

Section P: COVID-19

132. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Virology

133. Global perspective and Epidemiology of COVID-19

134. Immunology and Diagnosis of SARS-CoV-2 and COVID-19

135. Clinical Manifestations of COVID-19 in Adults and Children

136. Treatment and Prevention of SARS-CoV-2 (COVID-19)

Section Q: Miscellaneous Syndromes

137. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

PART III: INFECTIOUS DISEASES AND THEIR ETIOLOGIC AGENTS
Section A: Viral Diseases

138. Biology of Viruses and Viral Diseases

139. Orthopoxviruses: Vaccinia (Smallpox Vaccine), Variola (Smallpox), Mpox, and Cowpox

140. Other Poxviruses That Infect Humans: (Including Orf Virus) Molluscum Contagiosum, and Yatapoxviruses

141. Introduction to Herpesviridae

142. Herpes Simplex Virus

143. Chickenpox and Herpes Zoster (Varicella-Zoster Virus)

144. Cytomegalovirus

145. Epstein-Barr Virus (Infectious Mononucleosis, Epstein-Barr Virus–Associated Malignant Diseases, and Other Diseases)

146. Human Herpesvirus Types 6 and 7 (Exanthem Subitum)

147. Kaposi’s Sarcoma–Associated Herpesvirus (Human Herpesvirus Type 8)

148. Herpes B Virus

149. Adenoviruses

150. Papillomaviruses

151. JC, BK, and Other Polyomaviruses: Progressive Multifocal Leukoencephalopathy, BK Nephropathy, and Merkel Cell Carcinoma

152. Hepatitis B Virus

153. Hepatitis D Virus

154. Human Parvoviruses, Including Parvovirus B19, Human Bocaviruses, and Adeno-Associated Viruses (AAVs)

155. Orthoreoviruses and Orbiviruses

156. Coltiviruses (Colorado Tick Fever Virus) and Seadornaviruses

157. Rotaviruses

158. Alphaviruses

159. Rubella Virus (German Measles)

160. Flaviviruses (Dengue, Yellow Fever, Japanese Encephalitis, West Nile Encephalitis, Usutu Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis, Powassan Encephalitis, Kyasanur Forest Disease, Alkhurma Hemorrhagic Fever, Zika)

161. Hepatitis C

162. Coronaviruses, Including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS)

163. Parainfluenza Viruses

164. Mumps Virus

165. Respiratory Syncytial Virus

166. Human Metapneumovirus

167. Measles Virus (Rubeola)

168. Zoonotic Paramyxoviruses: Nipah, Hendra, and Menangle Viruses

169. Vesicular Stomatitis Virus and Related Vesiculoviruses (Chandipura Virus)

170. Rabies (Rhabdoviruses)

171. Marburg and Ebola Virus Hemorrhagic Fevers

172. Influenza Viruses, Including Avian Influenza and Swine Influenza

173. Bunyavirus Infections: Hantavirus Syndromes, La Crosse encephalitis, Rift Valley Fever, Crimean-Congo Hemorrhagic Fever, and Others

174. Lymphocytic Choriomeningitis Virus, Lassa Virus, Lujo Virus, and the South American Hemorrhagic Fever Viruses (Arenaviruses)

175. Human T-Lymphotropic Virus

176. Introduction to the Human Enteroviruses and Parechoviruses

177. Poliovirus

178. Coxsackieviruses, Echoviruses and Numbered Enteroviruses (EVD-68, EVD-70, EV-A71) )

179. The Human Parechoviruses

180. Hepatitis A Virus

181. Rhinovirus

182. Noroviruses and Sapoviruses (Caliciviruses)

183. Astroviruses and Picobirnaviruses

184. Hepatitis E Virus

Section B: Prion Diseases

185. Prions and Prion Diseases of the Central Nervous System (Transmissible Neurodegenerative Diseases)

Section C: Chlamydial Diseases

186. Chlamydia Trachomatis (Urogenital Infections and Trachoma)

187. Psittacosis (Due to Chlamydia psittaci)

188. Chlamydia Pneumoniae

Section D: Mycoplasma Diseases

189. Mycoplasmoides (Mycoplasma) pneumoniae

190. Genital Mycoplasmas: Mycoplasma Genitalium, Mycoplasma Hominis, Ureaplasma Species

Section E: Rickettsioses, Ehrlichioses, and Anaplasmoses

191. Introduction to Rickettsioses, Ehrlichioses, and Anaplasmosis

192. Rickettsia Rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers)

193. Coxiella Burnetii (Q Fever)

194. Rickettsia Prowazekii (Epidemic or Louse-Borne Typhus)

195. Rickettsia Typhi (Murine Typhus)

196. Orientia Tsutsugamushi (Scrub Typhus)

197. Ehrlichia chaffeensis, Anaplasma phagocytophilum, and Other Anaplasmataceae

Section F: Bacterial Diseases

198. Introduction to Bacteria and Bacterial Diseases

Sub-Section I. Infections due to Gram-Positive Bacteria

199. Staphylococcus Aureus

200. Staphylococcus Epidermidis and Other Coagulase-Negative Staphylococci

201. Classification of Streptococci

202. Streptococcus Pyogenes (Group A streptococcus)

203. Nonsuppurative Poststreptococcal Sequelae: Rheumatic Fever and Glomerulonephritis

204. Streptococcus Pneumoniae

205. Enterococcus Species, Streptococcus Gallolyticus Group and Leuconostoc Species

206. Streptococcus Agalactiae (Group B Streptococcus)

207. Viridans Streptococci, Nutritionally Variant Streptococci, and Groups C and G Streptococci

208. Streptococcus Anginosus Group

209. Corynebacterium Diphtheriae (Diphtheria)

210. Other Coryneform Bacteria and Rhodococci

211. Listeria Monocytogenes

212. Bacillus Anthracis (Anthrax)

213. Bacillus Species and Related Genera Other Than Bacillus Anthracis

214. Erysipelothrix Rhusiopathiae

215. Whipple Disease

Sub-Section II. Infections due to Gram-Negative Bacteria

216. Neisseria Meningitidis

217. Neisseria Gonorrhoeae (Gonorrhea)

218. Moraxella Catarrhalis, Kingella, and Other Gram-Negative Cocci

219. Vibrio Cholerae

220. Other Pathogenic Vibrios

221. Campylobacter Jejuni and Related Species

222. Helicobacter Pylori and Other Gastric Helicobacter Species

223. Enterobacterales (Enterobacteriaceae)

224. P. Aeruginosa and Other Pseudomonas Species

225. Stenotrophomonas Maltophilia and Burkholderia Cepacia Complex

226. Burkholderia Pseudomallei and Burkholderia Mallei: Melioidosis and Glanders

227. Acinetobacter Species

228. Salmonella Species

229. Bacillary Dysentery: Shigella and Enteroinvasive Escherichia coli

230. Haemophilus Species, Including H. Influenzae and H. ducreyi

231. Brucellosis (Brucella Species)

232. Francisella Tularensis (Tularemia)

233. Pasteurella Species

234. Plague (Yersinis Pestis)

235. Yersinia Enterocolitica and Yersinia Pseudotuberculosis

236. Bordetella Pertussis

237. Rat-Bite Fever: Streptobacillus Moniliformis and Spirillum Minus

238. Legionnaires’ Disease and Pontiac Fever

239. Capnocytophaga Species

240. Bartonella, Including Cat-Scratch Disease

241. Klebsiella Granulomatis (Donovanosis, Granuloma Inguinale)

242. Other Gram-Negative and Gram-Variable Bacilli

Sub-Section III. Infections due to Spirochetal Bacteria

243. Syphilis (Treponema Pallidum)

244. Endemic Treponematoses

245. Leptospira Species (Leptospirosis)

246. Relapsing Fevers Due to Borrelia Species

247. Lyme Disease (Lyme Borreliosis) Due to Borrelia Burgdorferi

Sub-Section IV. Infections due to Anaerobic Bacteria

248. Anaerobic Infections: General Concepts

249. Clostridioides (Clostridium) difficile Infection

250. Tetanus (Clostridium Tetani)

251. Botulism (Clostridium Botulinum)

252. Diseases Caused by Clostridium

253. Bacteroides, Prevotella, Porphyromonas, and Fusobacterium Species (And Other Medically Important Anaerobic Gram-Negative Bacilli)

254. Anaerobic Cocci and Anaerobic Gram-Positive Nonsporulating Bacilli

Sub-Section V. Infections due to Acid-Fast Organisms

255. Mycobacterium Tuberculosis

256. Leprosy (Mycobacterium Leprae)

257. Mycobacterium Avium Complex

258. Infections Caused by Nontuberculous Mycobacteria Other Than Mycobacterium Avium Complex

259. Nocardia Species

260. Agents of Actinomycosis

Section G: Mycoses

261. Introduction to Mycoses

262. Candida Species

263. Aspergillus Species

264. Agents of Mucormycosis and Entomophthoramycosis

265. Sporothrix Schenckii

266. Chromoblastomycosis

267. Mycetoma

268. Cryptococcosis (Cryptococcus Neoformans and Cryptococcus Gattii)

269. Histoplasma Capsulatum (Histoplasmosis)

270. Blastomycosis

271. Coccidioidomycosis (Coccidioides Species)

272. Dermatophytosis (Ringworm) and Other Superficial Mycoses

273. Paracoccidioidomycosis

274. Uncommon Fungi and Related Species

275. Pneumocystis Species

276. Microsporidiosis

Section H: Protozoal Diseases

277. Introduction to Protozoal Diseases

278. Entamoeba Species, Including Amebic Colitis and Liver Abscess

279. Free-Living Amebae

280. Malaria (Plasmodium Species)

281. Leishmania Species: Visceral, Cutaneous, and Mucosal

282. Trypanosoma Species (American Trypanosomiasis, Chagas Disease): Biology of Trypanosomes

283. Agents of African Trypanosomiasis (Sleeping Sickness)

284. Toxoplasma Gondii

285. Giardia Lamblia

286. Trichomonas Vaginalis

287. Babesia Species

288. Cryptosporidiosis (Cryptosporidium Species)

289. Cyclospora Cayetanensis, Isospora Belli, Sarcocystis Species, Balantidium Coli, and Blastocystis Species

Section I: Diseases Due to Toxic Algae

290. Human Illness Associated With Cyanobacteria and Harmful Algal Blooms, Including Fish and Shellfish Poisoning Syndromes

Section J: Diseases Due to Helminths

291. Introduction to Helminth Infections

292. Intestinal Nematodes (Roundworms)

293. Tissue Nematodes, Including Trichinellosis, Dracunculiasis, and the Filariases

294. Trematodes (Schistosomes and Liver, Intestinal and Lung Flukes)

295. Tapeworms (Cestodes)

296. Visceral Larva Migrans and Other Uncommon Helminth Infections

Section K: Ectoparasitic Diseases

297. Introduction to Ectoparasitic Diseases

298. Lice (Pediculosis)

299. Scabies

300. Myiasis and Tungiasis

301. Mites, Including Chiggers

Section L: Diseases of Unknown Etiology

302. Ticks, Including Tick Paralysis

303. Kawasaki Disease

PART IV: SPECIAL PROBLEMS
Section A: Nosocomial Infections

304. Infection Prevention and Control in the Healthcare Setting

305. Disinfection, Sterilization, and Hospital Waste

306. Infections Caused by Percutaneous Intravascular Devices

307. Nosocomial Pneumonia

308. Catheter-Associated Urinary Tract Infection (CAUTI) and Catheter-Associated Asymptomatic Bacteriuria (CA-ASB)

309. Transfusion- and Transplantation-Transmitted Infections

Section B: Infections in Special Hosts

310. Infections in the Immunocompromised Host: General Principles

311. Prophylaxis and Empirical Therapy of Infection in Cancer Patients

312. Infections in Recipients of Hematopoietic Cell Transplantation +CAR-Tcell infections

313. Infections in Solid organ Transplant Recipients

314. Infections in Older Adults

315. Infections in Asplenic Patients

316. Infections in Persons Who Inject Drugs

Section C: Surgical- and Trauma-Related Infections

317. Surgical Site Infections and Antimicrobial Prophylaxis

318. Burns

319. Infections Following Traumatic Injuries

320. Bites

Section D: Immunization

321. Principles of immunization and public health

322. Immunizations for Specific Infections

Section E: Protection of Travelers

323. Protection of Travelers

324. Infections in Returning Travelers

Section F: Emerging Issues in Infectious Diseases

325. Zoonoses

326. Communicating about Infectious Diseases to the Public

327. Basic Principles in Climate Change and Infectious Diseases