Contents
Biographies vii
Preface to the Fifth Edition ix
About the Companion Website xi
Part 1 Concepts 1
1 Microbial pathogens, classification and concepts 2
2 Innate and acquired immunity 4
3 The ‘normal’ flora in health and disease 6
4 Pathogenicity and pathogenesis of infectious disease 8
5 Making a microbiological diagnosis of infection 10
6 Antimicrobial therapy – principals and concepts 12
7 Antibacterial agents – pharmacology and modes of action 14
8 Antimicrobial use and stewardship 16
9 Emergence and detection of resistance 18
10 Sources and transmission of infection 20
11 Principles of infection control 22
12 Infection in the healthcare environment 24
13 Immunization 26
14 Emerging infections 28
15 High consequence infectious diseases and bioterrorism preparedness 30
Part 2 Bacteriology 33
16 Staphylococcus 34
17 Haemolytic streptococcal infections 36
18 Other Gram- positive cocci and the alpha- haemolytic streptococci 38
19 Streptococcus pneumoniae 40
20 Listeria, bacillus, non‐diphtheria corynebacterium 42
21 Diphtheria, tetanus and pertussis 44
22 Mycobacterium tuberculosis 46
23 Non- tuberculous mycobacteria and leprosy 48
24 Clostridium 50
25 Non- sporing anaerobic infections 52
26 Neisseria and Moraxella 54
27 Small Gram- negative coccobacilli: Haemophilus, Brucella, Francisella, Yersinia and Bartonella 56
28 Pathogenicity of enteric Gram‐negative bacteria 58
29 Enterobacteriaceae clinical syndromes 60
30 Vibrio, Campylobacter and Helicobacter 62
31 Environmental pathogens: Pseudomonas, Burkholderia, Legionella and Acinetobacter 64
32 Chlamydia, Mycoplasma and Rickettsia 66
33 Spiral bacteria 68
Part 3 Virology 71
34 Virus structure and classification 72
35 Antiviral therapy 74
36 Herpesviruses I 76
37 Herpesviruses II 78
38 DNA viruses: adenovirus, parvovirus and poxvirus 80
39 Measles, mumps and rubella 82
40 Influenza viruses 84
41 Parainfluenza and other respiratory viruses 86
42 Enterovirus and viruses that infect the gastrointestinal tract 88
43 Hepatitis viruses 90
44 Tropical, exotic or arbovirus infections 92
Part 4 Mycology 95
45 Yeast infections 96
46 Filamentous fungi 98
47 Antifungal drugs and antifungal therapy 100
Part 5 Parasitology 103
48 Intestinal protozoa 104
49 Malaria, leishmaniasis and trypanosomiasis 106
50 Intestinal helminths 108
51 Tissue helminths 110
Part 6 Systemic infection 113
52 Congenital and perinatal infections 114
53 HIV infection and AIDS 116
54 Pyrexia of unknown origin and puerperal sepsis 118
55 Sepsis 120
56 Endocarditis, myocarditis and pericarditis 122
57 Infections of the central nervous system 124
58 Acute respiratory tract infections 126
59 Chronic infections of the lung and hospital acquired pneumonia 128
60 Urinary and genital infections 130
61 Infections of the bones and joints 132
62 Bacterial diarrhoeal disease 134
63 Zoonoses 136
64 Infections in immunocompromised patients 138
65 Ocular infections 140
66 Infections of the skin and soft tissue 142
Index 144
reface
Part 1 Concepts
1 Microbial pathogens, classification and concepts
2 Innate and acquired immunity
3 The ‘normal’ flora in health and disease,
4 Pathogenicity and pathogenesis of infectious disease
5 Making a microbiological diagnosis of infection
6 Antimicrobial therapy – principles and concepts
7 Antibacterial agents – pharmacology and modes of action
8 Antimicrobial use and stewardship
9 Emergence and detection of resistance
10 Sources and transmission of infection
11 Principles of infection control
12 Infection in the healthcare environment
13 Immunization
14 Emerging infections
15 High consequence infectious diseases and bioterrorism preparedness
Part 2 Bacteriology
16 Staphylococcus
17 Haemolytic Streptococcal infections
18 Other Gram-positive cocci and the alpha-haemolytic streptococci
19 Streptococcus pneumoniae
20 Listeria, Bacillus, non-diphtheria Corynebacterium
21 Diphtheria, tetanus and pertussis
22 Mycobacterium tuberculosis
23 Non tuberculous mycobacteria and leprosy
24 Clostridium
25 Non-sporing anaerobic infections
26 Neisseria and Moraxella
27 Small Gram-negative coccobacilli: Haemophilus, Brucella, Francisella, Yersinia and Bartonella
28 Pathogenicity of enteric Gram-negative bacteria
29 Enterobacteriaceae clinical syndromes
30 Vibrio, Campylobacter and Helicobacter
31 Environmental pathogens: Pseudomonas, Burkholderia, Legionella and Acinetobacter
32 Chlamydia, Mycoplasma and Rickettsia
33 Spiral bacteria
Part 3 Virology
34 Virus structure and classification
35 Antiviral therapy
36 Herpesviruses I
37 Herpesviruses II
38 DNA viruses: adenovirus, parvovirus and poxvirus
39 Measles, mumps and rubella
40 Influenza viruses
41 Parainfluenza and other respiratory viruses
42 Enterovirus and viruses that infect the gastrointestinal tract
43 Hepatitis viruses
44 Tropical, exotic or arbovirus infections
Part 4 Mycology
45 Yeast infections
46 Filamentous fungi
47 Antifungal drugs and anti-fungal therapy
Part 5 Parasitology
48 Intestinal protozoa
49 Malaria, leishmaniasis and trypanosomiasis
50 Intestinal helminths
51 Tissue helminths
Part 6 Systemic infection
52 Congenital and perinatal infections
53 HIV infection and AIDS
54 Pyrexia of unknown origin and puerperal sepsis
55 Sepsis
56 Endocarditis, myocarditis and pericarditis
57 Infections of the central nervous system
58 Acute Respiratory tract infections
59 Chronic infections of the lung and Hospital acquired pneumonia
60 Urinary and genital infections
61 Infections of the bones and joints
62 Bacterial diarrhoeal disease
63 Zoonoses
64 Infections in immunocompromised patients
65 Ocular infections
66 Infections of the skin and soft tissue
Index
