Περιγραφή
The presentation of hematolymphoid and histiocytic diseases can vary widely between children and adults as can age-related differential diagnoses and the consequences of treatment. Providing up to date information and classification for diseases across the hematopoietic, lymphoid and histiocytic systems, the book also covers morphologic, immunophenotypic, cytogenetic, and molecular genetic features of routine and diagnostically challenging disorders in pediatric patients. Over 200 high-quality colour illustrations aid accurate diagnosis and correct interpretations when evaluating peripheral blood, bone marrow, lymph nodes and other tissues specimens. This comprehensive yet practical guide also discusses useful ancillary tests and introduces newly recognised entities identified in the current literature, such as GATA-2 haploinsufficiency, B-ALL with DUX4-IGH and ERG deletion, and ALK-positive histiocytosis. An online version of the book with expandable figures can be accessed on Cambridge Core, via the code printed on the inside of the cover.
- Contains over 200 high-quality colour images that are fully annotated to aid accurate diagnosis and correct interpretations when evaluating peripheral blood, bone marrow, lymph node and other tissue specimens
- Approaches the subject from a practical standpoint, providing quick but authoritative answers to clinicians who may encounter patients with these diseases in their everyday clinical practice
- Readers can gain full HTML access of the whole book with expandable figures via a scratch-off code inside the cover
Περιεχόμενα
Section I. General Hematology and Hematopathology:
1. Development of hematopoiesis in fetus, at birth and after birth Xiayuan Liang
2. Normal anatomy and function of lymph node Xiayuan Lian
Section II. Non-Neoplastic Hematologic Disorders of Blood and Bone Marrow:
3. Anemia Virginia Knez and Xiayuan Liang
4. Bone marrow failure syndromes Bradford Siegele
5. Inherited leukocyte disorders Bradford Siegele
6. Other conditions Virginia Knez and Xiayuan Liang
Section III. Non-Neoplastic Disorders of Extramedullary Lymphoid Tissues:
7. Non-infectious lymphadenopathy Xiayuan Liang
8. Infectious lymphadenopathy Julie Rosser and Xiayuan Liang
Section IV. Neoplastic Disorders Of Bone Marrow:
9. Ancillary tests Bradford Siegele, Liming Bao, Amy L. Treece and Xiayuan Liang
10. Juvenile myelomonocytic leukemia Bradford Siegele
11. Myeloid/lymphoid neoplasms with eosinophilia & gene rearrangement Bradford Siegele
12. Myelodysplastic/myeloproliferative neoplasms/Chronic myeloid leukemia, BCR-ABL1+ Bradford Siegele
13. Childhood myelodysplastic syndromes (MDS) Bradford Siegele
14. Acyte myeloid leukemia with related precursor neoplasms Xiayuan Liang, Billie Carstens and Virginia Knez
15. Myeloid neoplasms with germline predisposition Bradford Siegele
16. Blastic plasmacytoid dendritic cell neoplasm (BPDCN) Bradford Siegele
17. Acute luekemia of ambiguous lineage Xiayuan Liang and Silvia Tse Bunting
18. Precursor lymphoid neoplasms Virginia Knez, Alexandra E. Kovach, Gordana Raca, Billie Carstens and Xiayuan Liang
19. Solid tumor metastasis to the bone marrow Xiayuan Liang
Section V. Mature Lymphoid Neoplasms:
20. Mature b-cell non-hodgkin neoplasms Xiayuan Liang
21. Mature t-cell and nk-cell non-hodgkin lymphomas Xiayuan Liang
22. Hodgkin lymphoma Xiayuan Liang
23. Immunedeficiency-assoicated lymphoproliferative disorders Xiayuan Liang
Section VI. Histiocytic Disorders and Neoplasms:
24. Histiocytic pathogenesis and derivation Jennifer Picarsic
25. Identification of macrophages and dendritic cells Jennifer Picarsic
26. Non-neoplastic accumulation of histiocytes Jennifer Picarsic
27. Hemophagocytic lymphohistiocytosis (HLH) Jennifer Picarsic and Rebecca Marsh
28. Histiocytic inflammatory neoplasms/lesions Jennifer Picarsic, Benjamin H. Durham and Ashish Kumar.
