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The 6 Ds of Fecal Microbiota Transplantation A Primer from Decision to Discharge and Beyond

ISBN: 9781630917500
ISBN: 9781630917500
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Περιγραφή

A practical handbook on fecal microbiota transplantation (FMT) for physicians, nurses, physician assistants, students, residents, and fellows, The 6 Ds of Fecal Microbiota Transplantation: A Primer from Decision to Discharge and Beyond provides a clinical framework to understand and administer this treatment as safely and effectively as possible.

FMT has emerged as a promising treatment for C. difficile infection (CDI), and there is a major need for educational resources on the topic. Drs. Jessica Allegretti, Zain Kassam, and their expert contributors are leaders in the field and have collectively cared for thousands of patients suffering from recurrent CDI who have benefitted from FMT.

This guide provides practical tools, clinical pearls, and answers to frequently asked questions. Beginning with introductory information on the microbiome and exploring the history of FMT, The 6 Ds of Fecal Microbiota Transplantation outlines a step-by-step checklist for administering FMT:

  • Decision: Who is the right CDI patient to receive FMT? What clinical questions should you ask patients in your FMT clinical assessment?
  • Donor: How do you select and screen a donor for FMT?
  • Discussion: What are the risks, benefits, and alternatives that need to be discussed with patients?
  • Delivery: What is the best delivery method for FMT—colonoscopy, nasogastric tube, enema, or capsules?
  • Discharge and follow-up: What is the ideal post-FMT care? How should you council patients following FMT?
  • Discovery: What are the most promising emerging clinical applications for FMT? What is the evidence for FMT in obesity, autism, irritable bowel syndrome, inflammatory bowel disease, antibiotic resistant bacteria, and liver disease?

Arming healthcare professionals with the ability to answer questions from patients regarding FMT and the microbiome, The 6 Ds of Fecal Microbiota Transplantation provides a pragmatic guide for this exciting treatment.

Περιεχόμενα

Dedication

Acknowledgments

 

About the Editors 

Contributing Authors

Chapter 1 Introduction Jessica R. Allegretti, MD, MPH and Zain Kassam, MD, MPH

Chapter 2 Microbiome 101 Suzanne Devkota, PhD

Chapter 3 The History of Fecal Microbiota Transplantation Joann Kwah, MD, FACG and Lawrence J. Brandt, MD, MACG, AGAF, FASGE

Chapter 4 Decision: Which Patients With Clostridioides difficile Infection Are Appropriate for Fecal Microbiota Transplantation? Abbas Rupawala, MD and Colleen R. Kelly, MD

Chapter 5 Decision: Considerations for Use of Fecal Microbiota Transplantation in Special Patient Populations Rohma Ghani, MBBS, MRCP and Benjamin H. Mullish, MB, BChir, MRCP, PhD

Chapter 6 Donor: How Do You Select and Screen Candidate Donors for Fecal Microbiota Transplantation? Shrish Budree, MBChB, DCH, FCPaeds, Cert. Paeds Gastro.

Chapter 7 Discussion: How Do You Discuss the Risks and Benefits of Fecal Microbiota Transplantation? Majdi Osman, MD, MPH and Pratik Panchal, MD, MPH

Chapter 8 Delivery: How Do You Select the Most Appropriate Delivery Modality for Fecal Microbiota Transplantation? Paul Feuerstadt, MD, FACG, AGAF and Neil Stollman, MD, FACP, FACG, AGAF

Chapter 9 Discharge: How Should You Follow and Care for Patients After Fecal Microbiota Transplantation? Lauren Tal Grinspan, MD, PhD and Ari M. Grinspan, MD

Chapter 10 Discovery: Emerging Indications Jessica R. Allegretti, MD, MPH and Zain Kassam, MD, MPH 10.1 | Other Clostridioides difficile Indications10.1.1 | The Role of Fecal Microbiota Transplantation in the Treatment of Primary Clostridioides difficile InfectionAlexander Khoruts, MD10.1.2 | The Role of Fecal Microbiota Transplantation in the Treatment of Severe and Fulminant Clostridioides difficile InfectionMonika Fischer, MD, MSc and Sára Nemes, BA 10.2 | Gastrointestinal Indications: What Have We Learned?10.2.1 | The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel DiseaseLindsey Russell, MD, MSc and Paul Moayyedi, MD, PhD, MPH10.2.2 | The Role of Fecal Microbiota Transplantation in the Treatment of PouchitisJennifer D. Claytor, MD, MS and Najwa El-Nachef, MD10.2.3 | The Role of Fecal Microbiota Transplantation in the Treatment of Irritable Bowel SyndromeNeena Malik, MD, MSc and Olga C. Aroniadis, MD, MSc 10.3 | The Role of Fecal Microbiota Transplantation in the Treatment of Liver DiseasesChathur Acharya, MD and Jasmohan S. Bajaj, MD, MS 10.4 | The Role of Fecal Microbiota Transplantation in the Treatment of Autism Spectrum DisorderThomas J. Borody, MD, PhD, DSc and Anoja W. Gunaratne, BAMS (Hon), MSc, PhD 10.5 | The Role of Fecal Microbiota Transplantation in the Decolonization of Antibiotic-Resistant BacteriaChristopher Saddler, MD and Nasia Safdar, MD, PhD 10.6 | The Role of Fecal Microbiota Transplantation in the Treatment of Obesity, Metabolic Syndrome, and Nonalcoholic Fatty Liver DiseaseBenjamin H. Mullish, MB, BChir, MRCP, PhD

Chapter 11 Frequently Asked Questions Jessica R. Allegretti, MD, MPH and Zain Kassam, MD, MPH Financial Disclosures

Index