Availability: Άμεσα Διαθέσιμο

The Sepsis Codex, 1st Edition

ISBN: 9780323882712
Εκδόσεις:
Διαστάσεις 24 × 19 cm
Μορφή

Εκδόσεις

Ημ. Έκδοσης

Σελίδες

Έκδοση

Συγγραφείς

,

Κύριος Συγγραφέας

Original price was: 127,00€.Η τρέχουσα τιμή είναι: 113,00€.(Περιλαμβάνεται ΦΠΑ 6%)

Διαθέσιμο - Προπαραγγελία|Διαθεσιμότητα: 11-14 ημέρες

Περιγραφή

Offering a global, multidisciplinary perspective on this life-threatening medical emergency, The Sepsis Codex provides a concise yet comprehensive look at a complex topic. Nearly 20% of global deaths are attributed to sepsis annually, nearly half of which are in children under the age of five, with low-resource settings being disproportionately affected. A “one size fits all” approach is not sufficient to meet individual patients’ needs, instead requiring a therapeutic approach that considers different ages, predisposing factors, genetic traits, and more. This cutting-edge resource brings you up to date with recent medical advances in this challenging area.
Key Features
  • Covers pathophysiology, early detection, biomarkers and diagnosis, therapies, controversies, future research, the use of AI, professional organizations and public health in sepsis.
  • Includes chapters on sepsis in special populations such as in pregnant women, transplanted patients, and children.
  • Consolidates today’s available information on this timely topic into a single, convenient resource.
Author Information
Edited by Marcio Borges, MD, Associate Professor of Infectious Disease Balearic Islands University; Coordinator, Multidisciplinary Sepsis Unit, Critical Care Medicine, Son Llatzer University Hospital, Palma de Mallorca, Spain ; Jorge Hidalgo, MD, MACP, MCCM, FCCP, Professor and Head, Division of Critical care, Karl Heusner Memorial Hospital, Belize, Central America and Javier Perez-Fernandez, MD, Medical Director, Critical Care Services Baptist Hospital of Miami, Florida, USA

Περιεχόμενα

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • List of Contributors
  • Preface
  • Acknowledgments
  • Part I. Introduction
  • Chapter 1. Sepsis: Past, Present, and Future—Lessons Learned from COVID-19
  • Conclusions
  • Chapter 2. Sepsis Definitions: A Historical Perspective
  • What Is Sepsis?
  • Sepsis Through the Years
  • Future Directions
  • Conclusions
  • Chapter 3. The Epidemiology of Sepsis
  • Introduction
  • Limitations and Challenges
  • Conclusions
  • Part II. Basic Concepts
  • Chapter 4. Pathophysiology of Sepsis
  • Introduction
  • Immunology
  • Endothelium
  • Shock and Organ Failure
  • The Neuroendocrine Response
  • Metabolic Response to Sepsis
  • Conclusion
  • Chapter 5. Sepsis and Microcirculation
  • Introduction
  • Macrocirculation
  • Microcirculation in Sepsis
  • Clinical Assessment
  • Skin Mottling
  • Peripheral Perfusion Index
  • Biochemical Markers
  • Plasma Lactate
  • Handheld Vital Microscopy
  • Chapter 6. Genetics and Sepsis
  • Genetics and Sepsis
  • Sepsis Response
  • Genetic Variability
  • Human Genome
  • Finding the Genes
  • Key Genes
  • Personalized and Precision Medicine
  • Part III. Diagnosis and Monitoring
  • Chapter 7. Screening and early detection of sepsis
  • Introduction
  • Limitations for sepsis detection
  • Early detection
  • Diagnosis
  • Bundle of the early detection
  • Experience and impact of the early sepsis detection
  • Other possibilities for early sepsis detection/screening
  • Summary
  • Chapter 8. Diagnosis and Monitoring of Sepsis
  • Introduction
  • Sepsis Definitions and Controversies
  • SIRS and Surrounding Controversies
  • Organ Dysfunction/Failure Criteria
  • Severity Scores: A Critical Assessment
  • Chapter 9. Sepsis: Molecular Diagnostics and Biomarkers
  • Introduction
  • Biomarkers as Clinical Tools
  • Established Biomarkers
  • Emerging Molecular Approaches
  • Nondiagnostic Utility of Biomarkers
  • Summary
  • Chapter 10. Hemodynamic Monitoring: Current Practice and New Perspectives
  • Introduction
  • Current Practice Based on International Experts’ Recommendations
  • Improvement of Available Minimally or Noninvasive Technologies
  • New Noninvasive Hemodynamic Monitoring Technologies
  • Clinical Application of Technologies Assessing Microcirculation Currently Used for Research Purpose
  • Automation/Artificial Intelligence/Machine Learning
  • Conclusion
  • Chapter 11. Point of Care Ultrasound in the Management of Sepsis
  • Objectives
  • Introduction
  • Case Presentation
  • Is POCUS Helpful in Managing This Patient?
  • Role of POCUS in the Diagnosis of Sepsis
  • Preload Sensitivity and Volume Responsiveness
  • Inferior Vena Cava Assessment
  • Tips and Tricks
  • Variations in the Left Ventricular Outflow Tract Velocity Time Interval
  • Passive Leg Raise Test
  • Tips and Tricks for Performing an Accurate PLR Test
  • Left Ventricle Systolic Dysfunction
  • Left Ventricle Diastolic Dysfunction
  • How to Assess?
  • Tips and Tricks
  • Right Ventricle Dysfunction in Sepsis
  • POCUS-Guided Management in Septic Shock
  • Key Points
  • Chapter 12. New Approaches and Understanding of Sepsis
  • Introduction
  • Monitoring Clinical Signs
  • Diagnosis
  • Monitoring with Biomarkers and Practical Application of Monitoring Systems in the Different Phases of Sepsis
  • Infectious Monitoring
  • Monitoring According with Organ Dysfunction
  • Treatment
  • Long-Term Outcome and Mortality
  • Chapter 13. Sepsis Quality Indicators in the Emergency Department
  • Introduction
  • Infection Prevention Indicators
  • Timing Indicators
  • Diagnostic Indicators
  • Perspectives
  • Part IV. Treatment
  • Chapter 14. Sepsis Treatment: Fluids
  • Introduction
  • Background: the Four D’s of Fluid Therapy
  • Basics of the Fluid Treatment in Sepsis: the ROSE Principle and Four Phases of Fluid Resuscitation
  • Fluids and Their Difference: Choosing the Right Drug
  • Chapter 15. Vasopressor Therapy in Septic Shock
  • Introduction
  • Understanding the Relevant Pathophysiology of Septic Shock
  • Noradrenaline
  • Adrenaline
  • Phenylephrine
  • Dopamine
  • NonCatecholamines
  • Vasopressin Analogs
  • Selepressin
  • Angiotensin II
  • Methylene Blue
  • Side Effects of Vasopressor Therapy
  • Principles of Vasopressor Therapy
  • Clinical Monitoring of Vasopressor Therapy
  • Weaning of Vasopressor Therapy
  • Vasopressor Sparing Strategies
  • Directions of Future Research
  • Conclusion
  • Key Points
  • Chapter 16. Mechanical Ventilation in Sepsis
  • Chapter 17. Extracorporeal Membrane Oxygenation for the Support of Patients with Refractory Septic Shock
  • Introduction
  • Hemodynamics of Septic Shock
  • Why Might ECMO be Effective in Patients With Refractory Septic Shock?
  • Indications
  • When Initiating ECMO
  • Predictor Risk Factor for ECMO in Septic Shock Patients
  • In Conclusion
  • Chapter 18. Antimicrobials in the Management of Sepsis
  • Timeliness of Therapy
  • Antimicrobial Stewardship
  • Choice of Antimicrobial Therapy
  • Antimicrobial Selection
  • Route of Administration
  • Antifungal Agents
  • Chapter 19. Kidney Support in Sepsis
  • Introduction
  • Fluid Management in AKI
  • RRT Principles
  • Renal Replacement Therapy
  • Intermittent Renal Replacement Therapy
  • Continuous Renal Replacement Therapy
  • Renal Dosage Adjustment for Antimicrobials
  • Chapter 20. Hematological Support in Sepsis
  • Introduction
  • The Endothelium
  • The White Blood Cells in Sepsis
  • The Red Blood Cells in Sepsis
  • The Platelets in Sepsis
  • Platelets Involvement
  • Coagulation Factors in Sepsis
  • General Approach of Sepsis-Induced Coagulopathy
  • Chapter 21. Specific Treatment of Focus Control in Sepsis
  • Introduction
  • Educational Goals of the Chapter
  • Epidemiology and Short-Term Outcome of Patients with Drainable Source of Sepsis
  • Focus Control into the Context of the General Principles of Sepsis Management
  • Usefulness of Ancillary Test for General Assessment in Patients with Potentially Focus Control of Sepsis
  • Organ System-Specific Focus Control of Sepsis
  • Chapter 22. Sepsis Adjunctive Therapies
  • Introduction
  • Glycemic Control
  • VTE Prophylaxis
  • Nutrition
  • Stress Ulcer Prophylaxis
  • Long-Term Outcomes
  • Palliative Care
  • Music Therapy
  • Sleep Therapy
  • Chapter 23. Glycemic Control and Stress Ulcer Prophylaxis
  • Glycemic Control
  • Stress Ulcer Prophylaxis
  • Chapter 24. Nutrition in Sepsis
  • Introduction
  • Pathophysiology of Sepsis and Its Impact on Metabolism
  • Nutrition in Sepsis
  • Enteral and Parenteral Feeding
  • Screening for Nutritional Risk in Septic Patients
  • Conclusions
  • Part V. Special Settings
  • Chapter 25. Fever in Intensive Care Units
  • Introduction
  • Definitions for Fever
  • Measurement of Fever
  • Pathogenesis of Fever
  • Significance of Fever
  • Fever Patterns
  • Causes of Fever in the ICU
  • A Treatment Approach for Critically Ill Febrile Patients
  • Initial Investigations
  • Diagnostic Evaluation
  • Infectious Causes of Fever
  • Noninfectious Causes of Fever in the ICU
  • Treatment of Fever in the ICU
  • Chapter 26. Sepsis—In the Era of Antimicrobial Resistance
  • Introduction
  • Epidemiology of AMR Sepsis
  • Antibiotic Resistance—Genetics
  • Treatment
  • Key Points
  • Chapter 27. Factors Underlying Racial and Gender Disparities in Sepsis Management
  • Introduction
  • Racial Disparities
  • Gender Disparities
  • Potential Target for Interventions to Reduce Disparities
  • Conclusion
  • Chapter 28. Sepsis in Special Populations
  • Sepsis and Obesity
  • Sepsis and Cancer
  • Sepsis and Solid Organ Transplant Recipients
  • Burns and Sepsis
  • Chapter 29. Comprehensive Management of Sepsis in Pediatrics
  • Epidemiology
  • Definition
  • Identifying Sepsis, Clinical Presentation, and Complementary Diagnostic Tests
  • Initial Clinical Assessment
  • Additional Diagnostic Tests for Sepsis
  • Etiology and Treatment With Antimicrobials
  • Controlling the Source of Infection
  • Hemodynamic Therapy
  • Initial Resuscitation and Fluid-Refractory Shock (See Table 29.6)
  • Catecholamine-Resistant Shock
  • Persistent Catecholamine-Resistant Shock and Refractory Shock
  • Other Therapeutic Measures
  • Chapter 30. Maternal Sepsis
  • Introduction
  • Physiological Changes During Pregnancy and Risk Factors
  • Diagnosis
  • Treatment
  • Perspectives
  • Part VI. Special Considerations
  • Chapter 31. Role of Preventive Measures in Sepsis
  • Introduction
  • Challenges
  • Etiology and Risk Factors
  • Preventive Measures
  • Conclusions
  • Chapter 32. Value of the Protocolization and Sepsis Performance Improvement Program in Early Identification
  • Introduction
  • Uniformity and Protocolization
  • Early Warning Digital Systems and Artificial Intelligence
  • High-Fidelity Simulation
  • Chapter 33. Long-Term Sequelae of Sepsis
  • Introduction
  • Long-Term Derangements in Sepsis Survivors
  • Part VII. Future Outlook
  • Chapter 34. New Diagnostic and Therapeutic Perspectives
  • Introduction
  • The Role of Translational Research
  • New Molecules for Adjuvant Treatment of Sepsis
  • Nanotechnology
  • Future Directions
  • Chapter 35. Artificial Intelligence in Sepsis
  • Introduction
  • A High-Level Overview of Artificial Intelligence Techniques in Healthcare
  • Machine Learning for Sepsis
  • Challenges with AI for Sepsis
  • Conclusions
  • Index