Περιγραφή
- A comprehensive new guide to the impact of chronic kidney disease on mineral homeostasis, the skeleton, vascular calcifications, and mortality
- Fully-updated, including new hormones, FGF-23 and klotho, and new treatment agents, calcimimetics, calcilytics, vitamin D analogs, and more to manage both conditions simultaneously
- Reflects new understanding of the relation of renal bone disease and cardiovascular disease
- Now in full colour throughout, including numerous colour illustrations
Despite significant improvement in the management of patients with chronic kidney disease, the morbidity and mortality remain high. However more is now understood about the hormonal influence on bone and vascular structures, and there have been major advances in the field of bone and mineral metabolism. This has lead to the development of new treatment strategies and agents.
This new second edition reflects the most current thinking and understanding in this fascinating field, as presented by world basic and clinical experts.
Readership: Nephrologists (specialists and trainees), researchers, endocrinologists and general physicians
Περιεχόμενα
1: Definition and classification of renal osteodystrophy and chronic kidney disease-mineral bone disorder (CKD-MBD)
2: New aspects of normal bone biology
3: Osteocytes and mineral metabolism
4: Calcium-sensing receptors (CaSRs) in kidney, bone and vessels
5: Regulation of parathyroid hormone biosynthesis and gene expression
6: Abnormal parathyroid gland function in CKD
7: PTHrP physiology and pathophysiology, and the PTH/PTHrP receptor
8: Vitamin D metabolism and action in CKD
9: Growth factors and cytokines in renal bone disease
10: Bone histomorphometry in renal osteodystrophy
11: The spectrum of renal osteodystrophy and vascular calcifications in uremia
12: Imaging of the skeleton and the joints in CKD
13: Non-invasive assessment of vascular calcification and arterial stiffness
14: Osteopenia in uremia
15: Acidosis and renal bone disease
16: Dialysis-associated amyloidosis
17: Pathogenesis of vascular calcification: experimental studies
18: Clinical consequences of arterial calcifications and soft-tissue calcifications in Chronic Kidney Disease
19: Clinical management of vascular and soft tissue calcifications in Chronic Kidney Disease patients
20: The role of the skeleton in the pathogenesis of vascular calcification in the Chronic Kidney Disease-Mineral Bone Disorder
21: Klotho: bone, kidney, vascular calcifications, and the ageing process
22: Physiology and pathology of calcium and magnesium transport
23: Phosphatonins in health and disease
24: FGF-23 in renal failure
25: New vitamin D analogs for chronic kidney disease patients
26: Calcimimetics and calcilytics in the treatment of chronic kidney disease-mineral and bone disorder
27: Medical therapy in chronic kidney disease
28: Chronic kidney disease-mineral and bone disorder (CKD-MBD) in children
29: Bone disease in renal transplant recipients
30: Imaging and intervention of parathyroid hyperplasia
31: Surgical management of secondary hyperparathyroidism
32: Morbidity and mortality related to disturbances in mineral metabolism in CKD
