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Volpe’s Neurology of the Newborn, 7th Edition

Joseph J. Volpe, Terrie E. Inder
ISBN: 9780443105135
ISBN: 9780443105135
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Διαστάσεις 28 × 22 cm
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Περιγραφή

Stay up to date with today’s latest advances in diagnosis and management, as well as the many scientific and technological advances that are revolutionizing neonatal neurology, with the definitive text in the field. Volpe’s Neurology of the Newborn, 7th Edition, shares the knowledge and expertise of world authority Dr. Joseph Volpe, who, along with Dr. Terrie E. Inder of Children’s Hospital of Orange County and other distinguished editors, brings a wealth of insight to this classic text. Known for its clear, engaging writing style, vibrant, full-color illustrations, and authoritative information throughout, this reference is an indispensable resource for those who provide care for neonates with neurological conditions.
Key Features
  • Provides clear, comprehensive coverage of neonatal neurology in Dr. Joseph Volpe’s own legendary, readable manner—for a masterful, cohesive source of answers to any question that arises in your practice.
  • Brings the latest science into the clinical setting, with an emphasis on translating new knowledge to the infant’s bedside.
  • Offers comprehensive updates with summary tables and text to reflect major advances in the study of hemorrhage; new insights into molecular genetics and molecular characterization of brain tumors; significant advances in drugs and the developing nervous system; and much more.
  • Includes new chapters on fetal neurology which address the importance of understanding and investigating the maternal-fetal origins of neonatal disease, as well as new chapters on neurodevelopmental follow-up, inflammation, and neurology in low-resource settings.
  • Contains more than 1,000 illustrations: clinical and pathological specimens, key experimental findings, schematics, algorithms, anatomical drawings, and neuroimaging throughout, as well as numerous tables and boxes that synthesize key points.
  • An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Any additional digital ancillary content may publish up to 6 weeks following the publication date.

Περιεχόμενα

Cover image
Title page
Table of Contents
Any screen, Any time, Anywhere
Copyright
Dedication
Contributors
Preface
Video Contents
Chapter 12
Chapter 37
Unit I: Human Brain Development
Chapter 1. Neural Tube Development
Abstract
Introduction
NORMAL DEVELOPMENT OF THE FUNDAMENTAL CENTRAL NEURO-AXIS
DISORDERS OF CRANIOSPINAL DEVELOPMENT
KEY REFERENCES
References
Chapter 2. Prosencephalic Development
Abstract
Normal Prosencephalic Development
Disorders of Prosencephalic Development
KEY REFERENCES
REFERENCES
Chapter 3. Ventricular Development, Ventriculomegaly, and Hydrocephalus in the Fetus and Newborn
Abstract
Introduction
Fetal Ventriculomegaly
Fetal Ventriculomegaly and Hydrocephalus
Management of Fetal Ventriculomegaly and Congenital Hydrocephalus
Prognosis of Fetal Ventriculomegaly and Congenital Hydrocephalus
KEY REFERENCES
REFERENCES
Chapter 4. Normal and Abnormal Development of the Posterior Fossa Structures
Abstract
NORMAL DEVELOPMENT OF THE BRAINSTEM AND CEREBELLUM
ABNORMAL DEVELOPMENT OF THE POSTERIOR FOSSA STRUCTURES
KEY REFERENCES
REFERENCES
Chapter 5. Neuronal Proliferation
Abstract
NEURONAL PROLIFERATION
Key References
References
Chapter 6. Neuronal Migration
Abstract
MIGRATION
KEY REFERENCES
REFERENCES
Chapter 7. Organizational Events
Abstract
NORMAL DEVELOPMENT
DISORDERS OF ORGANIZATIONAL EVENTS
DISORDERS OF MULTIPLE ORGANIZATIONAL EVENTS DELINEATED IN VIVO RELATED TO PREMATURITY-ASSOCIATED FACTORS
Conclusions
KEY REFERENCES
References
Chapter 8. Myelination Events
Abstract
NORMAL DEVELOPMENT
DISORDERS
KEY REFERENCES
REFERENCES
Unit II: Fetal Neurology
Chapter 9. Specialized Diagnostic Studies for Assessment of the Fetal Central Nervous System
Abstract
INTRODUCTION
IMAGING THE FETAL BRAIN
GENETIC EVALUATION OF FETAL BRAIN ANOMALIES
Conclusions
KEY REFERENCES
REFERENCES
Chapter 10. Placental Conditions With Consequences for the Fetal Brain
Abstract
DEVELOPMENT OF NORMAL PLACENTAL STRUCTURE AND FUNCTION
ABNORMAL PLACENTAL DEVELOPMENT
KEY REFERENCES
REFERENCES
Chapter 11. Maternal and Fetal Conditions With Consequences for the Fetal Brain
Abstract
ENDOCRINE DISORDERS IN PREGNANCY AND THE DEVELOPING FETAL BRAIN
MATERNAL MENTAL HEALTH DISORDERS OF PREGNANCY, FETAL BRAIN DEVELOPMENT, AND LONG-TERM NEUROPSYCHOLOGIC OUTCOME
FETAL CONDITIONS WITH SECONDARY ADVERSE EFFECTS ON THE FETAL BRAIN: CONGENITAL HEART DISEASE AND FETAL BRAIN DEVELOPMENT
KEY REFERENCES
REFERENCES
Unit III: Neurological Evaluation
Chapter 12. Neurological Examination: Normal and Abnormal Features
Abstract
INTRODUCTION
NORMAL NEUROLOGICAL EXAMINATION
ABNORMAL NEUROLOGICAL FEATURES
VALUE OF THE NEONATAL NEUROLOGICAL EXAMINATION
KEY REFERENCES
REFERENCES
Chapter 13. Specialized Neurological Studies
Abstract
CEREBROSPINAL FLUID EXAMINATION
NEUROPHYSIOLOGICAL STUDIES
Acknowledgement
KEY REFERENCES
REFERENCES
Chapter 14. Neurodevelopmental Follow-Up of High-Risk Newborns
Abstract
INTRODUCTION
PRIMARY PURPOSE OF NEURODEVELOPMENTAL FOLLOW-UP
NEURODEVELOPMENT
WHICH INFANTS NEED FOLLOW-UP
MODELS OF NEURODEVELOPMENTAL FOLLOW-UP
TIMING OF FOLLOW-UP ASSESSMENTS
NEURODEVELOPMENTAL FOLLOW-UP PROGRAMS
FUNCTIONAL NEURODEVELOPMENTAL DOMAINS
CONCLUSIONS
Acknowledgment
KEY REFERENCES
REFERENCES
Unit IV: Seizures
Chapter 15. Neonatal Seizures
ABSTRACT
INTRODUCTION
PATHOPHYSIOLOGY
CLASSIFICATION
ETIOLOGY
DIAGNOSIS
PROGNOSIS
MANAGEMENT
KEY REFERENCES
REFERENCES
Unit V: Hypoxic-Ischemic and Related Disorders
Chapter 16. Pathophysiology: General Principles
Abstract
DEFINITIONS
CAUSES OF PATHOLOGICAL HYPOXIA-ISCHEMIA
THE EVOLUTION OF CEREBRAL INJURY
PRIMARY MEDIATORS OF HYPOXIC-ISCHEMIC INJURY IN THE NEWBORN BRAIN—PHYSIOLOGICAL AND BIOCHEMICAL
CONCLUSIONS
KEY REFERENCES
REFERENCES
Chapter 17. Inflammation and the Newborn Brain
Abstract
INTRODUCTION
EPIDEMIOLOGICAL AND CLINICAL EVIDENCE OF THE INPUT OF INFLAMMATION AND NEUROINFLAMMATION IN TERM NEWBORNS
EPIDEMIOLOGICAL AND CLINICAL EVIDENCE OF THE IMPACT OF INFLAMMATION AND NEUROINFLAMMATION IN PRETERM NEWBORNS
IMMUNE MEDIATORS
NEUROINFLAMMATION IN NEONATAL ENCEPHALOPATHY: EXPERIMENTAL STUDIES IN HYPOXIC-ISCHEMIC MODELS
SYSTEMIC INFLAMMATION, NEUROINFLAMMATION, AND BILATERAL COMMUNICATION IN PRETERM NEWBORNS
IMPACT OF NEUROINFLAMMATION ON THE PRETERM BRAIN
THE TERTIARY PHASE OF NEUROINFLAMMATION IN PRETERM INFANTS
IMPLICATIONS FOR NEUROPROTECTIVE STRATEGIES IN NEWBORNS
KEY REFERENCES
REFERENCES
Chapter 18. Encephalopathy of Prematurity: Neuropathology
Abstract
NEUROPATHOLOGICAL FEATURES OF THE ENCEPHALOPATHY OF PREMATURITY
ENCEPHALOPATHY OF PREMATURITY—NEUROPATHOLOGY IN LIVING INFANTS
KEY REFERENCES
REFERENCES
Chapter 19. Encephalopathy of Prematurity: Pathophysiology
Abstract
OVERVIEW OF PATHOGENESIS
PRETERM CEREBRAL GRAY MATTER INJURY AND DYSMATURATION
KEY REFERENCES
REFERENCES
Chapter 20. Encephalopathy of the Preterm—Clinical Aspects
Abstract
INTRODUCTION
CLINICAL SETTINGS
NEUROLOGIC SYNDROME
DIAGNOSIS
PROGNOSIS AND CLINICOPATHOLOGICAL CORRELATIONS
MANAGEMENT
CONCLUSION
Acknowledgement
KEY REFERENCES
REFERENCES
Chapter 21. Intrauterine and Intrapartum Assessment of the Fetus
Abstract
ANTEPARTUM ASSESSMENT
INTRAPARTUM ASSESSMENT
KEY REFERENCES
References
Chapter 22. Hypoxic-Ischemic Encephalopathy in the Term Infant: Neuropathology
Abstract
Neuropathology
KEY REFERENCES
References
Chapter 23. Hypoxic-Ischemic Injury in the Term Infant: Pathophysiology
Abstract
Introduction
PART A
PART B
KEY REFERENCES
References
Chapter 24. Hypoxic-Ischemic Injury in the Term Infant: Clinical-Neurological Features, Diagnosis, Imaging, Management, and Prognosis
Abstract
CLINICAL SETTINGS
NEUROLOGICAL SYNDROME
Diagnosis
COMPUTED TOMOGRAPHY
MAGNETIC RESONANCE IMAGING
CLINICOPATHOLOGICAL CORRELATIONS
Management
Prognosis
KEY REFERENCES
References
Chapter 25. Stroke in the Newborn
Abstract
CLASSIFICATION—NOMENCLATURE
PERINATAL ARTERIAL ISCHEMIC STROKE
CEREBRAL SINOVENOUS THROMBOSIS
KEY REFERENCES
References
Unit VI: Intracranial Hemorrhage
Chapter 26. Intracranial Hemorrhage: Subdural, Subarachnoid, Subpial, Intraventricular (Term Infant), Miscellaneous
Abstract
Overview
SUBDURAL HEMORRHAGE
PRIMARY SUBARACHNOID HEMORRHAGE
INTRAVENTRICULAR HEMORRHAGE OF THE TERM INFANT
SUBPIAL HEMORRHAGE
MISCELLANEOUS EXAMPLES OF NEONATAL INTRACRANIAL HEMORRHAGE
KEY REFERENCES
References
Chapter 27. Cerebellar Hemorrhage
Abstract
CEREBELLAR HEMORRHAGE: FETUS
CEREBELLAR HEMORRHAGE: PRETERM INFANT
CEREBELLAR HEMORRHAGE: TERM INFANT
KEY REFERENCES
References
Chapter 28. Preterm Intraventricular Hemorrhage/Posthemorrhagic Hydrocephalus
Abstract
MAGNITUDE OF THE PROBLEM
Neuropathology
Pathogenesis
CLINICAL FEATURES
Diagnosis
Prognosis
Management
Conclusions
KEY REFERENCES
References
Unit VII: Metabolic Encephalopathies
Chapter 29. Glucose
Abstract
Introduction
Definition
NORMAL METABOLIC ASPECTS
BIOCHEMICAL ASPECTS OF HYPOGLYCEMIA
Neuropathology
CLINICAL ASPECTS
KEY REFERENCES
References
Chapter 30. Bilirubin and Brain Injury
Abstract
NORMAL BILIRUBIN STRUCTURE AND METABOLISM
Pathophysiology
Neuropathology
CLINICAL ASPECTS OF ACUTE AND CHRONIC BILIRUBIN ENCEPHALOPATHIES
KEY REFERENCES
References
Chapter 31. Amino Acids
Abstract
OVERVIEW OF AMINOACIDOPATHIES WITH NEONATAL NEUROLOGICAL MANIFESTATIONS
MAPLE SYRUP URINE DISEASE
NONKETOTIC HYPERGLYCINEMIA
HYPERAMMONEMIA
ACQUIRED DISORDERS WITH NEONATAL HYPERAMNONEMIA
MISCELLANEOUS AMINO ACID DISORDERS
KEY REFERENCES
REFERENCES
Chapter 32. Organic Acids
Abstract
OVERVIEW OF MAJOR ORGANIC ACID DISORDERS AND NEONATAL METABOLIC ACIDOSIS
DISORDERS OF PROPIONATE AND METHYLMALONATE METABOLISM
DISORDERS OF PYRUVATE AND MITOCHONDRIAL ENERGY METABOLISM
DISORDERS OF BRANCHED-CHAIN KETOACID METABOLISM
DISORDERS OF FATTY ACID OXIDATION
OTHER ORGANIC ACID DISORDERS
KEY REFERENCES
REFERENCES
Unit VIII: Degenerative Disorders
Chapter 33. Degenerative Disorders of the Newborn
Abstract
MAJOR DISORDERS
DISORDERS PRIMARILY AFFECTING GRAY MATTER
DISORDERS PRIMARILY AFFECTING WHITE MATTER
DISORDERS AFFECTING BOTH GRAY AND WHITE MATTER
KEY REFERENCES
REFERENCES
Unit IX: Neuromuscular Disorders
Chapter 34. Evaluation, Special Studies
Abstract
MOTOR SYSTEM
EVALUATION OF DISORDERS OF THE MOTOR SYSTEM
KEY REFERENCES
REFERENCES
Chapter 35. Arthrogryposis Multiplex Congenita
Abstract
CLINICAL FEATURES
PATHOGENESIS
CLINICAL CLASSIFICATION
DIAGNOSIS
MANAGEMENT
KEY REFERENCES
REFERENCES
Chapter 36. Levels Above Lower Motor Neuron to Neuromuscular Junction
Abstract
LEVELS ABOVE THE LOWER MOTOR NEURON
LEVEL OF THE LOWER MOTOR NEURON
LEVEL OF THE PERIPHERAL NERVE
LEVEL OF THE NEUROMUSCULAR JUNCTION
KEY REFERENCES
REFERENCES
Chapter 37. Muscle Involvement and Restricted Disorders
Abstract
LEVEL OF THE MUSCLE
RESTRICTED NEUROMUSCULAR DISORDERS
DISTINGUISHING FEATURES OF DISORDERS OF THE MOTOR SYSTEM
KEY REFERENCES
REFERENCES
Unit X: Intracranial Infections
Chapter 38. Viral, Protozoan, and Related Intracranial Infections
Abstract
DESTRUCTIVE VERSUS TERATOGENIC EFFECTS
TORCH INFECTIONS
OTHER VIRUSES
KEY REFERENCES
References
Chapter 39. Bacterial and Fungal Intracranial Infections
Abstract
BACTERIAL MENINGITIS
BRAIN ABSCESS
DISSEMINATED FUNGAL INFECTION
TETANUS NEONATORUM
Acknowledgment
KEY REFERENCES
REFERENCES
Unit XI: Perinatal Trauma
Chapter 40. Injuries of Extracranial, Cranial, Intracranial, Spinal Cord, and Peripheral Nervous System Structures
Abstract
INTRODUCTION
MAJOR VARIETIES OF PERINATAL TRAUMA
INJURY TO EXTRACRANIAL, CRANIAL, AND CENTRAL NERVOUS SYSTEM STRUCTURES
INJURY TO PERIPHERAL NERVOUS SYSTEM STRUCTURES
KEY REFERENCES
REFERENCES
Unit XII: Intracranial Mass Lesions
Chapter 41. Brain Tumors and Vein of Galen Malformations
Abstract
BRAIN TUMORS
VEIN OF GALEN MALFORMATION
ARACHNOID CYSTS
KEY REFERENCES
References
Unit XIII: Drugs and the Developing Nervous System
Chapter 42. Passive Addiction and Teratogenic Effects
Abstract
MAJOR FACTORS INVOLVED IN NEUROLOGIC DISTURBANCES ASSOCIATED WITH INTRAUTERINE DRUG EXPOSURE
DEVELOPMENTAL CONSEQUENCES FOR THE INFANT
Alcohol
ANTIEPILEPTIC DRUGS
Stimulants
Opioids
Antidepressants
Sedatives
Anesthetics
Marijuana
DRUG USE AND THE PRETERM INFANT
Conclusions
KEY REFERENCES
References
Unit XIV: Neurology in Low Resource Settings
Chapter 43. Neonatal Neurology in the Low-Resource Setting for the Term and Preterm Newborn
Abstract
Introduction
HIE/NE IN THE TERM-BORN NEWBORN
PREMATURE INFANTS IN THE LRS—IVH
KEY REFERENCES
References
Index
Confidence is ClinicalKey

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